摘要
目的:探讨肺部感染患儿血清IL-6、IL-8、SAA水平变化及其与严重程度的关系。方法:选取2022年6月到2024年6月本院收治肺部感染患儿72例为观察组,另选取同期健康体检儿童72例为对照组,比较两组研究对象血清IL-6、IL-8、SAA水平;依据严重程度将肺部感染患儿分为危重组(n=23)与轻症组(n=49),比较危重组和轻症组患儿血清IL-6、IL-8、SAA水平。并使用受试者工作特征(ROC)曲线分析IL-6、IL-8、SAA对患儿肺部感染严重程度的诊断价值。结果:观察组IL-6、IL-8、SAA水平高于对照组(P<0.05);危重组IL-6、IL-8、SAA水平高于轻症组(P<0.05),ROC曲线分析结果显示IL-6、IL-8、SAA均对肺部感染患儿疾病严重程度具有诊断价值,而联合诊断价值更高(P<0.05)。结论:肺部感染患儿血清IL-6、IL-8、SAA水平升高,IL-6、IL-8、SAA水平对肺部感染严重程度有诊断价值,且联合诊断价值更高。
Objective:To explore changes of serum interleukin-6(IL-6),interleukin-8(IL-8)and serum amyloid A(SAA),and their relationship with disease severity in children with pulmonary infection.Methods:A total of 72 children with pulmonary infection and 72 healthy children in the hospital were enrolled as observation group and control group between June 2022 and June 2024,respectively.The levels of serum IL-6,IL-8 and SAA were compared between the two groups.According to disease severity,children with pulmonary infection were divided into severe group(n=23)and mild group(n=49),and levels of serum IL-6,IL-8 and SAA in the two groups were compared.The diagnostic value of IL-6,IL-8 and SAA in the severity of pulmonary infection was analyzed by receiver operating characteristic(ROC)curves.Results:The levels of IL-6,IL-8 and SAA were higher in observation group than control group(P<0.05).The levels of IL-6,IL-8 and SAA were higher in severe group than mild group(P<0.05).The results of ROC curves analysis showed that IL-6,IL-8 and SAA were all of diagnostic value in the severity of pulmonary infection,and diagnosis value of combined detection was higher(P<0.05).Conclusion:The levels of serum IL-6,IL-8 and SAA are increased in children with pulmonary infection.IL-6,IL-8 and SAA all have diagnostic value in the severity of pulmonary infection,and diagnosis value of combined detection is higher.
作者
邹芳
万晨茜
Zou Fang;Wan Chen-qian(Department of Laboratory Medicine,Xinyu Hospital of Traditional Chinese Medicine,Xinyu 338000,Jiangxi,China;Department of Laboratory Medicine,Xinyu People's Hospital,Xinyu 338000,Jiangxi,China)
