摘要
为制备综合性能良好的海藻酸钙泡沫敷料,将质量分数为1%~5%的海藻酸钠溶液进行冷冻干燥,再经氯化钙交联和甘油增塑,制备出海藻酸钙泡沫敷料,并对该敷料的形貌结构、力学性能、吸水性能、止血性能和血液相容性进行测试分析。结果表明:海藻酸钙泡沫敷料为多孔结构,随着海藻酸钠浓度的增加,泡沫敷料表观密度增加,孔隙率降低,干湿态压缩强度增加,吸水率降低,凝血指数降低,红细胞吸附率增加。其中质量分数3%海藻酸钠溶液制备的泡沫敷料干态压缩强度为(68.59±7.40) kPa,湿态压缩强度为(2.90±0.12) kPa,吸水率为(24.45±1.03)倍,凝血指数为(18.97±0.50)%,溶血率为(1.68±0.58)%,具有良好的综合性能,在止血敷料领域具有较大的应用潜力。
Blood facilitates material exchange between tissues and organs and is crucial for maintaining normal physiological functions in organisms.When arteries—especially major arteries—rupture and fail to achieve timely hemostasis,human life is critically endangered.Blood loss exceeding one-third of total blood volume can induce shock or even death.Therefore,the rational application of hemostatic dressings is very important.However,traditional hemostatic materials(e.g.,gauze and bandages)exhibit significant limitations,including inadequate hemostatic efficacy,poor degradability,and adherence to wounds that causes secondary injury.To systematically address these issues,polysaccharide modification strategies have become central to developing novel hemostatic dressings.Sodium alginate—a linear polysaccharide extracted from brown algae or seaweed—possesses excellent hydrophilicity,biocompatibility,biodegradability,and non-immunogenicity,making it widely applicable in biomedical materials.Common modification strategies include ion exchange reactions and crosslinking with polyvalent metal ions.When sodium alginate's carboxyl groups crosslink with polyvalent metal ions,it forms an"egg-box structure",significantly enhancing mechanical strength and conferring water insolubility.This study employed sodium alginate as the base material to prepare porous foam precursors via freeze-drying.Subsequent crosslinking in calcium chloride solution,plasticization with glycerol,and secondary freeze-drying yielded calcium alginate foam dressings at varying concentrations.The microstructure,mechanical properties,water absorption,degradability,hemostatic efficacy,and biocompatibility of these dressings were systematically evaluated.Results demonstrated that foam dressings prepared from 3%sodium alginate solution exhibited optimal overall performance.These dressings featured relatively regular pore structures,suitable dry/wet compressive strength,and outstanding water absorption exceeding 20 times their weight.They demonstrated excellent hemostatic performance,with a coagulation index of 18.98%and an erythrocyte adhesion and adsorption rate of 29.02%.Additionally,the dressings showed favorable blood compatibility with a hemolysis rate of only 1.69%.In summary,this foam dressing preparation method is simple and cost-effective.The resulting dressings possess appropriate mechanical properties,exceptional water absorption,effective hemostasis,and high biocompatibility,meeting clinical requirements for hemostatic materials.This work provides reference for the development of new hemostatic dressings,and has great application potential.
作者
张逸松
刘颖
丁恺蒂
王奉基
陈冬
丁雪佳
ZHANG Yisong;LIU Ying;DING Kaidi;WANG Fengji;CHEN Dong;DING Xuejia(College of Materials Science and Engineering,Beijing University of Chemical Technology,Beijing 100029,China;School of Materials Science and Engineering,Zhengzhou University,Zhengzhou 450000,China;National Engineering Research Center for Rubber and Plastic Molds,Zhengzhou University,Zhengzhou 450000,China)
出处
《现代纺织技术》
北大核心
2025年第12期131-137,共7页
Advanced Textile Technology
基金
国家重点研发计划项目(2020YFC1107300)。
关键词
泡沫敷料
冷冻干燥
海藻酸钙
吸水
止血
血液相容性
foam dressing
freeze drying
calcium alginate
water absorption
hemostasis
blood compatibility
