摘要
目的探讨生长抑素联合奥美拉唑胃镜下给药治疗急性上消化道出血的疗效及对患者凝血功能的影响。方法选取2021年9月至2023年8月赣州市南康区第二人民医院收治的66例急性上消化道出血患者作为研究对象,按照随机数字表法分为对照组与联合组,每组33例。对照组给予生长抑素治疗,联合组在对照组的基础上加用奥美拉唑胃镜下给药治疗。比较两组临床疗效、治疗后康复相关指标、血常规指标[RBC、血小板计数(platelet count,PLT)和血红蛋白(hemoglobin,Hb)]、凝血功能指标[D-二聚体(D-dimer,D-D)、纤维蛋白原(fibrinogen,Fg)、部分凝血酶活化时间(activated partial thromboplastin time,APTT)、凝血酶原时间(prothrombin time,PT)]。结果联合组治疗总有效率高于对照组,差异有统计学意义(P<0.05);联合组出血停止时间、住院时间均短于对照组,输血量少于对照组,差异有统计学意义(P<0.05);治疗后,两组RBC、PLT和Hb水平均高于治疗前,且联合组高于对照组,差异有统计学意义(P<0.05);治疗后,两组APTT、PT均短于治疗前,且联合组短于对照组,两组D-D水平均低于治疗前,且联合组低于对照组,两组Fg水平均高于治疗前,且联合组高于对照组,差异有统计学意义(P<0.05)。结论生长抑素联合奥美拉唑胃镜下给药治疗急性上消化道出血的效果较单纯使用生长抑素更佳,能有效缩短患者出血时间,减少输血量,改善患者凝血功能。
Objective To investigate the efficacy of somatostatin combined with omeprazole under gastroscopy in the treatment of acute upper gastrointestinal bleeding and its effect on coagulation function of patients.Methods A total of 66 patients with acute upper gastrointestinal bleeding admitted to the Second People's Hospital of Nankang District,Ganzhou City,from September 2021 to August 2023 were selected as the research subjects,they were divided into the control group and the combined group according to the random number table method,with 33 cases in each group.The the control group was treated with somatostatin,and the the combined group was treated with omeprazole under gastroscopy on the basis of the the control group.The clinical efficacy,rehabilitation-related indicators after treatment,blood routine indicators(RBC,platelet count[PLT]and hemoglobin[Hb]),coagulation function indicators(D-dimer[D-D],fibrinogen[Fg],activated partial thromboplastin time[APTT],prothrombin time[PT])were compared between the two groups.Results The total effective rate in the combined group was higher than that in the control group,and the difference was statistically significant(P<0.05).The bleeding stop time and hospitalization time in the combined group were shorter than those in the control group,and the blood transfusion volume was less than that in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of RBC,PLT and Hb of the two groups were higher than those before treatment,and the combined group were higher than the control group,the differences were statistically significant(P<0.05).After treatment,the APTT and PT of the two groups were shorter than those before treatment,the combined group was shorter than the control group,the D-D levels of the two groups were lower than those before treatment,the combined group was lower than the control group,the Fg levels of the two groups were higher than those before treatment,the combined group was higher than the control group,the differences were statistically significant(P<0.05).Conclusion The effect of somatostatin combined with omeprazole under gastroscopy in the treatment of acute upper gastrointestinal bleeding is better than that of somatostatin alone,which can effectively shorten the bleeding time,reduce the amount of blood transfusion and improve the coagulation function of patients.
作者
吴道首
薛建龙
董文超
WU Daoshou;XUE Jianlong;DONG Wenchao(Department of Gastroenterology,the Second People's Hospital of Nankang District,Ganzhou City,Ganzhou,Jiangxi,341400,China)
出处
《当代医学》
2025年第12期61-64,共4页
Contemporary Medicine
关键词
生长抑素
奥美拉唑
急性上消化道出血
疗效
凝血功能
Somatostatin
Omeprazole
Acute upper gastrointestinal bleeding
Curative effect
Coagulation function
