摘要
目前,溃疡性结肠炎(ulcerative colitis,UC)全球发病率逐年攀升,传统疗法难以有效修复受损组织并重建免疫稳态,且临床缓解率普遍低于50%,大多数患者面临治疗耐药、黏膜屏障不可逆损伤及纤维化等难题,亟需新型治疗手段。近年研究发现,骨髓间充质干细胞(bone marrow mesenchymal stem cells,BMSCs)凭借多向分化潜能与炎症趋化特性,通过分泌抗炎介质及免疫调节蛋白精准调控微环境,显著促进结肠黏膜再生与功能恢复。基于这些发现,BMSCs已成为UC治疗领域的重要研究方向。因此,本文整合现有治疗体系,系统解析BMSCs治疗机制,以期为UC的治疗提供新的理论依据和临床指导。
Currently,the global incidence rate of ulcerative colitis(UC)is increasing year by year.Conventional therapies cannot effectively repair damaged tissue and reconstruct immune homeostasis,with a clinical remission rate of<50%,and most of the patients are facing problems such as drug resistance,irreversible damage to the mucosal barrier,and fibrosis,which require novel therapeutic methods.Recent studies have shown that bone marrow mesenchymal stem cells(BMSCs),with the help of their characteristics of multipotential differentiation and inflammatory chemotaxis,can precisely modulate the microenvironment by secreting anti-inflammatory mediators and immunomodulatory proteins and significantly promote the regeneration and functional recovery of colonic mucosa.Based on these findings,BMSCs have become an important research direction in the field of UC treatment.Therefore,this article integrates existing therapeutic systems and systematically analyzes the therapeutic mechanism of BMSCs,in order to provide a new theoretical basis and clinical guidance for the treatment of UC.
作者
王甜甜
米博文
王海强
Wang Tiantian;Mi Bowen;Wang Haiqiang(The First Clinical Medical College of Heilongjiang University of Chinese Medicine;Second Department of Gastroenterology,The First Affiliated Hospital of Heilongjiang University of Chinese Medicine)
出处
《重庆医科大学学报》
北大核心
2025年第11期1594-1600,共7页
Journal of Chongqing Medical University
基金
国家自然科学基金资助项目(编号:PYMS202501016)
国家中医药管理局第五批全国中医临床优秀人才研修资助项目(编号:国中医药人教函[2022]1号)
黑龙江中医药大学“优秀青年骨干教师”计划资助项目(编号:15041190018)。
关键词
骨髓间充质干细胞
溃疡性结肠炎
归巢
免疫调节
肠道微生态
bone marrow mesenchymal stem cells
ulcerative colitis
homing
immune regulation
gut microecology
