摘要
神经母细胞瘤(NB)是最常见的儿童颅外实体肿瘤,具有死亡率高和预后差等特点。随着分子生物学和基因组学研究的深入,研究者们逐渐认识到NB的发生发展涉及复杂的分子网络调控异常。为了开发更为安全且高效的精准诊治策略,深入剖析NB发病的分子机制就显得尤为重要。为深化对该疾病的理解,本文系统地从肿瘤发展进程(异常增殖、迁移侵袭及EMT等)、炎症反应以及细胞凋亡3个维度,综述了部分关键调控因子及其研究进展。本文重点探讨了MYCN、ALK、BDNF和PHOX2B等基因对NB细胞恶性生物学行为的调控机制,分析了NF-κB、COX-2/PGE2、MyD88和HMGB1等炎症信号的促瘤作用,并阐述了Bcl-2家族、p53-MDM2轴以及TRAIL等凋亡相关因子的作用机制。这些研究成果不仅深化了我们对NB分子病理机制的认识,更为重要的是揭示了多个具有转化潜力的治疗靶点,为NB的基础研究和临床治疗提供系统的理论参考,推动从分子机制到临床转化的研究进程,最终实现改善患儿预后的目标。
Neuroblastoma(NB)is the most common extracranial solid tumor in children,characterized by high mortality and poor prognosis.With advances in molecular biology and genomics research,it has become increasingly clear that the development and progression of NB are driven by the dysregulation of complex molecular networks.To develop safer and more efficient precision diagnostic and therapeutic strategies,it is particularly important to gain a deeper understanding of the molecular mechanisms underlying the pathogenesis of NB.This article systematically reviews research progress on key regulatory factors from three dimensions:tumor development(including abnormal proliferation,migration,invasion,and EMT),inflammatory responses,and apoptosis.We examined the effects of various genes,including MYCN,ALK,BDNF,and PHOX2B,on malignant behaviors of NB cells,analyzed the tumor-promoting effects of inflammatory signals,including NF-κB,COX-2/PGE2,MyD88,and HMGB1,and illustrated the mechanisms of apoptosis-related factors,including the Bcl-2 family,p53-MDM2 axis,and TRAIL.These findings deepen our understanding of the molecular pathological mechanisms of NB,and more importantly,reveal multiple therapeutic targets with translational potential,providing systematic theoretical references for basic research and clinical treatment.More broadly,this review is expected to promote further research from molecular mechanisms to clinical translation,ultimately aiming to improve the prognosis of pediatric patients.
作者
陈蕙卉
边佳昕
蔡嘉斌
丁浙玉
肖锐
顾伟忠
陶挺
王金湖
CHEN Huihui;BIAN Jiaxin;CAI Jiabin;DING Zheyu;XIAO Rui;GU Weizhong;TAO Ting;WANG Jinhu(Children’s Hospital,Zhejiang University School of Medicine,National Clinical Research Center for Child Health,Children’s Cancer Research Center,Hangzhou 310052,China;Biosan(Hangzhou)Clinical laboratory Co.,Ltd.,Hangzhou 310024;Binjiang Institute of Zhejiang University,Hangzhou 310053;Department of Pediatric Surgery,Children’s Hospital,Zhejiang University School of Medicine,Hangzhou 310052;Department of Pathology,Children’s Hospital,Zhejiang University School of Medicine,Hangzhou 310052;Key Laboratory of Neonatal Diseases of Zhejiang Province,Hangzhou 310052;Cancer Institute of Zhejiang University,Hangzhou 310058)
出处
《中国比较医学杂志》
北大核心
2025年第11期170-180,共11页
Chinese Journal of Comparative Medicine
基金
浙江省“尖兵”“领雁”研发攻关计划项目(2024C03181,2025C01106)。
关键词
神经母细胞瘤
发展进程
炎症反应
凋亡
调控因子
研究进展
neuroblastoma
development process
inflammatory response
apoptosis
regulatory factors
research progress
