摘要
肺部疾病是全球死亡和发病的主要原因之一,常见的表现包括咳嗽、咯痰、呼吸困难、胸痛等,主要包括慢性阻塞性肺部疾病、肺纤维化、肺癌和哮喘。研究证明全球暴露于有毒气体、传染性微生物和外界致敏原会导致这些肺部疾病的发生,并且反复接触这些物质会导致慢性气道炎症和过度的肺组织损伤。尽管在治疗这些疾病方面取得了巨大进步,但在开发安全有效的治疗药物方面仍然迫在眉睫。传统针对肺部疾病的治疗药物,由于缺乏特异针对性,大多都具有副作用,有时可产生相当严重的反应。目前对肺部疾病现有治疗方法可缓解症状、控制病情、改善肺功能以及降低病情恶化率,但进一步改善肺功能和减少病情恶化的方法仍未得到完善,尤其是对现有治疗方法无效的患者。靶向治疗可以明显降低副作用,且能显著提高疗效,随着对肺部疾病分子机制的研究,多个新的肺部治疗潜在靶点被提出,为更加精准的靶向治疗提供了可能。文章综述了肺部疾病靶点研究中的经典靶点,通过总结现有潜在靶点的相关研究成果,预测新靶点的研究方向,旨在为开发新的肺部潜在靶向治疗手段提供新思路。
Lung disease is one of the leading causes of death and morbidity worldwide,and its common manifestations include cough,sputum,dyspnea,and chest pain.Common lung diseases include chronic obstructive pulmonary disease,pulmonary fibrosis,lung cancer,and asthma.A growing body of research has shown that global exposure to toxic gases,infectious agents and external allergens contributes to the development of these lung diseases.Repeated exposure to these substances can lead to chronic airway inflammation and excessive lung tissue damage.Despite tremendous progress in the treatment of these diseases,there is still a pressing need to development of safe and effective therapeutic agents.Most of the traditional therapeutic drugs for lung diseases have side effects,sometimes producing quite severe reactions,and lack specificity.Currently available treatments for lung diseases provide symptomatic relief with disease control,improving lung function and reducing exacerbation rates,but there still remains an unmet need for further improving lung function and reducing exacerbations,particularly for those not responsive to currently available treatments,and the current clinical therapy is unable to reverse the pathogenesis and only delays the progression of lung diseases.The complex pathogenesis of lung disease has inspired researchers to explore a variety of biomolecular targeted therapies against specific targets.Targeted therapy could significantly reduce side effects and significantly improved efficacy.With the research on the molecular mechanisms of lung diseases,several new potential targets for lung therapy have been proposed,providing the possibility of more precise potential target therapy.The classical targets in the research of lung disease are reviewed in this paper,and the research direction of new targets is predicted by summarizing the relevant research results of existing potential targets,aiming to provide new ideas for developing new potential targets for lung therapeutics.A better understanding of new targets may provide new insights into future therapeutic strategies targeting the lung diseases.
作者
马川
王小娟
杨宝乐
景临林
马慧萍
MA Chuan;WANG Xiaojuan;YANG Baole;JING Linlin;MA Huiping(Department of Pharmacy,the 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army,Lanzhou 730050,China;Department of Pharmacy,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China)
出处
《药物生物技术》
2025年第5期703-712,共10页
Pharmaceutical Biotechnology
基金
国家自然科学基金资助项目(No.81872796)
甘肃省自然科学基金(No.22JR11RA011)
甘肃省卫生行业科研计划项目(No.GSWSKY-2019-62)
联勤保障部队第九四○医院专项培育项目(No.2021yxky015)。
