摘要
近年来随着核酸检测技术的发展,输血传播乙型肝炎病毒(HBV)的风险已显著降低,但仍有输血传播残余风险。献血筛查中暴露的隐匿性HBV感染问题日益受到关注。本文从隐匿性HBV感染的流行病学特征、感染机制、传统和新型诊断标志物、输血传播风险因素与残余风险评估等方面进行综述,以期为提高血液检测质量,降低HBV输血传播风险,确保献血者血液安全提供借鉴。
In recent years,the development of nucleic acid testing(NAT)have significantly reduced the risk of hepatitis B virus(HBV)transmission through blood transfusion.However,a residual risk persists.Occult hepatitis B virus infection(OBI),identified during blood donor screening,has become a growing concern for transfusion safety.This review summarizes the epidemiological characteristics,infection mechanism,traditional and novel diagnostic markers,risk factors for transfusion transmission,and assessments of residual risk of OBI,in order to provide reference for improving the quality of blood screening,reducing the risk of HBV transfusion transmission and ensuring the blood safety of blood donors.
作者
王蕊
王波
于洋
WANG Rui;WANG Bo;YU Yang(Department of Transfusion Medicine,The First Medical Center,Chinese PLA General Hospital,Beijing 100853,China;The Southern Medical Branch of PLA General Hospital,Beijing 100071,China)
出处
《中国输血杂志》
2025年第11期1627-1633,共7页
Chinese Journal of Blood Transfusion
