摘要
近年来,细胞焦亡作为一种程序性细胞死亡方式,在代谢性疾病研究领域逐渐受到广泛关注。细胞焦亡与炎症反应存在密切联系。越来越多的研究表明,细胞焦亡不仅在炎症反应的调控过程中发挥重要作用,还可通过多种途径对代谢状态、细胞功能以及组织损伤产生影响,从而在代谢性疾病的进展过程中起到加剧或缓解的作用。然而,目前对于细胞焦亡的具体分子机制及其在不同代谢性疾病中的作用尚未明确,相关治疗靶点的探索也处于初步阶段。系统阐述细胞焦亡在代谢性疾病中的作用机制,深入探讨其在炎症反应及病理生理学中的潜在作用机制,有望为未来代谢性疾病的防治研究提供更深入的思路和策略,推动该领域研究的进一步发展。
In recent years,pyroptosis,an inflammatory form of programmed cell death,has gained increasing attention in the field of metabolic disease research.Pyroptosis is closely associated with inflammatory responses.A growing body of evidence suggests that pyroptosis not only plays a critical role in regulating inflammation but can also influence metabolic status,cellular function,and tissue damage through multiple pathways,thereby either exacerbating or alleviating the progression of metabolic diseases.However,the precise molecular mechanisms of pyroptosis and its roles across different metabolic diseases remain unclear,and investigations into related therapeutic targets are still in early stages.Systematically elucidating the mechanisms by which pyroptosis contributes to metabolic diseases and exploring its potential roles in inflammation and pathophysiology may provide new insights and strategies for the prevention and treatment of metabolic disorders,and further promote advances in this research field.
作者
陈荣翠
王玮
CHEN Rongcui;WANG Wei(Department of Endocrinology,First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science&Technology,Mongolia 014010,China)
出处
《中南大学学报(医学版)》
北大核心
2025年第8期1465-1474,共10页
Journal of Central South University (Medical Science)
基金
内蒙古自然科学基金(2024MS08018)
包头医学院科学研究发展基金(BYJJ-GCJH 202517)。
关键词
代谢性疾病
细胞焦亡
炎症
病理调控
治疗靶点
metabolic diseases
cell pyroptosis
inflammation
pathological regulation
therapeutic targets
