摘要
阿尔茨海默病(AD)是最常见的神经退行性疾病之一,且目前尚无彻底治愈方法,常规的药物治疗可暂时缓解或稳定症状,但无法阻止疾病的长期进展。中药治疗AD疗效显著,且与西医疗法联用可起到增效减毒的功效。因此,从中药中寻找有效的抗AD药物已经成为热门的研究领域。中药的多组分特性使得其发挥药理作用具有多途径、多靶点、多通路的优势,总结目前研究发现的具有防治AD作用的中药(黄芪、人参、淫羊藿、巴戟天、当归、银杏叶等)成分(组分)改善AD的作用靶点、分子信号通路及复杂的调控网络,阐明中药成分(组分)发挥治疗AD作用的机制,为AD的临床治疗及从中药成分(组分)中发现新的AD治疗药物提供思路和参考。
Alzheimer's disease(AD)is one of the most common neurodegenerative diseases,and there is no complete cure yet.Conventional drug therapy can temporarily alleviate or stabilize symptoms,but cannot prevent the long-term progression of the disease.Traditional Chinese medicine has significant therapeutic effects on AD,and when combined with western medicine therapy,it can enhance efficacy and reduce toxicity.Therefore,finding effective anti ad drugs from traditional Chinese medicine has become a hot research field.The multi-component characteristics of traditional Chinese medicine make it have the advantages of multi-channel,multi-target and multi-channel to play its pharmacological role.This paper summarizes the components(components)of traditional Chinese medicine(Astragali Radix,Ginseng Radix et Rhizoma,Epimedii Folium,Morindae Officinalis Radix,Angelicae Sinensis Radix,Ginkgo Folium,etc.)with the effect of preventing and treating AD,which can improve the action targets,molecular signaling pathways and complex regulatory networks of AD,and clarify the mechanism of traditional Chinese medicine components in the treatment of AD,so as to provide ideas and references for the clinical treatment of AD and the discovery of new ad therapeutic drugs from traditional Chinese medicine components.
作者
裴金英
温晶钰
刘斌
董晓红
丛树园
钮雪松
万金来
PEI Jinying;WEN Jingyu;LIU Bin;DONG Xiaohong;CONG Shuyuan;NIU Xuesong;WAN Jinlai(Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China;Yunnan University of Traditional Chinese Medicine,Kunming 650500,,China;Traditional Chinese Medicine Outpatient Department of the Marine Warehouse of the Golden Needle Research Society,Beijing 100020,China;Tangshan Traditional Chinese Medicine Hospital,Tangshan 063000,China)
出处
《药物评价研究》
北大核心
2025年第10期3003-3016,共14页
Drug Evaluation Research
基金
黑龙江省自然科学基金资助项目(LH2023H073)。
关键词
阿尔茨海默病
中药组分
黄芪
人参
淫羊藿
巴戟天
当归
银杏叶
Alzheimer’s disease
components of traditional Chinese medicine
Astragali Radix
Ginseng Radix et Rhizoma
Epimedii Folium
Morindae Officinalis Radix
Angelicae Sinensis Radix
Ginkgo Folium
