摘要
瓜子金为苗族民间常用草药,近年来瓜子金在神经系统中的药理研究取得了积极进展,发现瓜子金具有改善学习记忆、减轻认知障碍、抑制神经炎症、抑制神经细胞凋亡、抗抑郁、抗氧化等广泛的药理作用。因此,本文对瓜子金在神经系统疾病中的作用及机制进行综述,以期为开发瓜子金防治神经系统疾病提供理论依据。
Polygala japonica Houtt.is a common herbal medicine in Miao people.In recent years,the pharmacological research of Polygala japonica in the nervous system has made positive progress,and it has been found that Polygala japonica has a wide range of pharmacological effects,such as improve learning and memory,reduce cognitive impairment,inhibition of neuroinflammation,inhibition of neuronal apoptosis,anti-depressant,and anti-oxidation.Therefore,this paper reviews the role and mechanism of Polygala japonica in nervous system diseases,in order to provide a theoretical basis for the development of Polygala japonica to prevent and treat nervous system diseases.
作者
刘顶鼎
杨菁
刘冬
王钧
杨许
曾贵荣
LIU Dingding;YANG Jing;LIU Dong;WANG Jun;YANG Xu;ZENG Guirong(Guizhou University of Traditional Chinese Medicine,Guiyang 550025,China;Hunan Provincial Drug Safety Evaluation Research Center&Key Laboratory of New Drug Pharmacodynamics and Safety Evaluation of Hunan Province,Changsha 410331,China)
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2020年第8期1015-1018,共4页
Chinese Journal of Modern Applied Pharmacy
基金
国家自然科学基金项目(81860844)
贵州省中医药、民族医药科学技术研究专项(QZYY-2016-001)
贵州省教育厅青年科技人才成长项目(黔教合KY字[2016]185)
贵州省科技计划项目(黔科合基础[2016]1016、黔科合基础[2019]1038号)
贵州省苗医药重点实验室开放课题(黔苗医药K字[2017]007、黔苗医药K字[2017]031)
全国大学生创新创业训练项目[贵中医大创合字(2018)13号]
贵阳中医学院一流专业(中药学)项目[贵中医一流专业大创合字(2017)158号]。
关键词
瓜子金
组分
阿尔茨海默病
帕金森病
抑郁症
脑缺血
Polygala japonica Houtt.
components
Alzheimer’s disease
Parkinson’s disease
depression
cerebral ischemia
