摘要
衰老受内在基因、细胞代谢,以及外在环境、生活习惯等多方面因素综合影响,其中表观遗传调控发挥着核心作用。表观遗传修饰包含DNA甲基化、组蛋白修饰、异染色质重塑、非编码RNA调控等,与三维基因组架构协同作用,对基因表达进行精准调控。该综述阐述了影响表观遗传调控的因素,以及表观遗传影响机体衰老的发生机制和干预策略,为揭示衰老机制、防治衰老相关疾病提供相关思路。
Aging is comprehensively influenced by multiple factors such as internal genes,cellular metabolism,external environment,and lifestyle habits.Among them,epigenetic regulation plays a core role.Epigenetic modifications,including DNA methylation,histone modification,heterochromatin remodeling,and non-coding RNA regulation,act in concert with the three-dimensional genome architecture to precisely regulate gene expression.This review elaborates on the factors influencing epigenetic regulation,as well as the mechanisms of how epigenetics affects the occurrence of organismal aging and the corresponding intervention strategies,providing relevant insights for uncovering the mechanisms of aging and preventing/treating aging-related diseases.
作者
张丽媛
史浩男
张文凤
张明倩
赵子阳
程真真
张体
闫振腾
孙建宁
董世芬
ZHANG Li-yuan;SHI Hao-nan;ZHANG Wen-feng;ZHANG Ming-qian;ZHAO Zi-yang;CHENG Zhen-zhen;ZHANG Ti;YAN Zhen-teng;SUN Jian-ning;DONG Shi-fen(School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 102488,China;Engineering Research Center for Pharmaceutics of Chinese Materia Medica and New Drug Development,Ministry of Education,Beijing 100029,China)
出处
《中国药理学通报》
北大核心
2025年第12期2230-2235,共6页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 81503287)
北京市自然科学基金资助项目(No 7232287)。
关键词
表观遗传调控
衰老
DNA甲基化
组蛋白修饰
RNA修饰
三维基因组架构
熵变
epigenetic regulation
aging
DNA methylation
histone modification
RNA modification
three-dimensional genome architecture
entropy change
