摘要
目的探讨降钙素原(PCT)联合营养指标对肝硬化营养状况的评定价值。方法选取2021年2月—2022年3月在右江民族医学院附属医院感染科住院的140例肝硬化患者,根据营养风险筛查2002(NRS 2002)将其分为有营养风险组和无营养风险组。比较两组肝硬化患者中营养指标体质指数(BMI)、血红蛋白(HGB)、前白蛋白(PA)、白蛋白(ALB)、视黄醇结合蛋白(RBP)水平,并分析它们与PCT的相关性。结果BMI、HGB、ALB、PA及RBP水平低于低营养风险组(P<0.05);营养指标(BMI、HGB、ALB、PA、RBP)与PCT呈负相关(P<0.05)。二元Logistics回归分析发现ALB、PCT是肝硬化患者营养风险的危险因素(P<0.05)。ROC结果显示PCT与ALB的联合营养指标评定肝硬化营养不良的曲线下面积为0.984,(95%CI:0.964~1.000),灵敏度98.8%,特异度93.3%,约登指数0.921;ALB、PCT的AUC分别为0.919、0.974。结论肝硬化患者PCT水平与其营养状况密切相关,对营养状况的评定有一定的价值,联合评定能有效提高其评定价值。
Objective To explore the value of procalcitonin(PCT)combined with nutritional indexes in evaluating the nutritional status of liver cirrhosis.Methods A total of 140 patients with cirrhosis admitted to the Department of Infection of the Affiliated Hospital of Youjiang Medical College for Nationalities from February 2021 to March 2022,they were selected and divided into with and without nutritional risk group according to nutritional risk screening 2002(NRS 2002).The levels of body mass index(BMI),hemoglobin(HGB),prealbumin(PA),albumin(ALB)and retinol binding protein(RBP)in two groups of patients with cirrhosis were compared,and the correlation between them and PCT was analyzed.Results The levels of BMI,HGB,ALB,PA and RBP were lower than those of low nutritional risk group(P<0.05).The nutritional indices(BMI,HGB,ALB,PA,RBP)were negatively correlated with PCT(P<0.05).Binary Logistics regression analysis showed that ALB and PCT were risk factors affecting nutritional risk in patients with cirrhosis(P<0.05).ROC results showed that the area under the curve was 0.984(95%confidence interval:0.964~1.000),sensitivity 98.8%,specificity 93.3%,and Yoden index 0.921 for the combined PCT and ALB indexes predicting malnutrition in cirrhosis.The AUC of ALB and PCT were 0.919 and 0.974,respectively.Conclusions The level of PCT in patients with cirrhosis is closely related to their nutritional status,which has certain value in the evaluation of nutritional status,and combined prediction can effectively improve the evaluation value.
作者
叶婷
罗雪清
黄美金
农照美
黄明凤
YE Ting;LUO Xueqing;HUANG Meijin;NONG Zhaomei;HUANG Mingfeng(Department of Nutrition,Affiliated Hospital of Youjiang Medical College for Nationalities,Baise 533000,China;Department of Ultrasound,Affiliated Hospital of Youjiang Medical College for Nationalities,Baise 533000,China;Department of Infectious Diseases,Affiliated Hospital of Youjiang Medical College for Nationalities,Baise 533000,China;Department of Prevention and Health,Affiliated Hospital of Youjiang Medical College for Nationalities,Baise 533000,China;Out-patient Department,Affiliated Hospital of Youjiang Medical College for Nationalities,Baise 533000,China)
出处
《广州医药》
2025年第10期1384-1389,共6页
Guangzhou Medical Journal
基金
广西壮族自治区卫生健康委员会自筹经费课题(Z20200278)。
关键词
降钙素原
肝硬化
营养状况
评定价值
procalcitonin
liver cirrhosis
nutritional status
assessed value
