摘要
慢性阻塞性肺疾病(COPD)是一种进展性持续、无法根治的呼吸系统疾病,是全球第三大致死原因。COPD的主要病理表现为肺部炎症反应,而巨噬细胞在炎症反应中发挥关键作用。M1型巨噬细胞分泌促炎介质,在炎症早期清除入侵病原体;M2型巨噬细胞则具有抗炎和组织修复作用。该文基于中医“阴阳平衡”理论,探讨了巨噬细胞极化在COPD免疫炎症中的作用机制,以期为治疗COPD提供新思路。在COPD的病理过程中,巨噬细胞极化状态失衡导致炎症反应持续存在,进一步加重病情。针对巨噬细胞极化在COPD发病中的特点,该文从炎症失衡、氧化应激、蛋白酶-抗蛋白酶平衡失调和代谢紊乱等方面,探讨了中医药通过调节巨噬细胞极化干预COPD的潜在机制。研究表明,多种中药成分可通过调控Toll样受体4/核转录因子-κB(TLR4/NF-κB)、丝裂原活化蛋白激酶(MAPK)等信号通路,影响巨噬细胞的极化状态,从而恢复M1/M2的动态平衡,减轻炎症反应。文章进一步提出基于“阴阳平衡”理论的COPD治疗策略,强调通过中医药干预巨噬细胞极化,调节免疫炎症反应,为COPD的综合防治提供了新的理论依据与治疗思路。
Chronic obstructive pulmonary disease(COPD)is a progressive,incurable respiratory disease and the third leading cause of death worldwide.The primary pathological manifestation of COPD is a pulmonary inflammatory response,in which macrophages play a key role.Ml macrophages secrete pro-inflammatory mediators,clearing invading pathogens in the early stages of inflammation.M2 macrophages have anti-inflammatory and tissue-repairing effects.This study explored the mechanism of macrophage polarization in the immunoinflammatory process of COPD based on the traditional Chinese medicine(TCM)theory of"Yin-Yang balance",aiming to provide new insights for COPD treatment.During the pathological process of COPD,an imbalance in macrophage polarization leads to persistent inflammatory responses,further exacerbating the condition.Given the characteristics of macrophage polarization in COPD pathogenesis,this study explored the potential mechanisms by which TCM modulates macrophage polarization to intervene in COpD,focusing on aspects such as inflammatory imbalance,oxidative stress,dysregulation of the protease-antiprotease balance,and metabolic disorders.Research indicated that various TCM components can influence macrophage polarization by regulating signaling pathways such as Toll-like receptor 4/nuclear factor-kB(TLR4/NF-κB)and mitogen-activated protein kinase(MAPK),thereby restoring the dynamic balance between Ml and M2 macrophages and alleviating inflammatory responses.The article further proposed a COPD treatment strategy based on the"Yin-Yang balance"theory and emphasized TCM intervention in macrophage polarization and regulation of immunoinflammatory responses.The study provides a new theoretical basis and treatment strategies for the comprehensive prevention and treatment of COPD.
作者
吴东升
李瑞洁
王彤彤
吴浩然
张珺
张炜
WU Dongsheng;LI Ruijie;WANG Tongtong;WU Haoran;ZHANG Jun;ZHANG Wei(Anhui University of Chinese Medicine,Hefei 230012,China;The First Hospital of Hunan University of Chinese Medicine,Changsha 410007,China;Shuguang Hospital of Shanghai University of Traditional Chinese Medicine(TCM),Shanghai 201203,China;Baoshan Hospital of Shanghai University of TCM,Shanghai 210999,China;Institute of Infectious Diseases,Shanghai Institute of TCM,Shanghai 201203,China)
出处
《中国实验方剂学杂志》
北大核心
2025年第23期223-230,共8页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(82405420)
上海市市级科技重大专项“重大突发传染病防控关键核心技术研究”项目(ZD2021CY001)
上海中医临床重点实验室项目(20DZ2272200)
张炜中医药传承创新工作室项目(2025CXGZS-01)
张炜宝山区名中医传承工作室项目(BSMZYGZS-2024-01)。
关键词
阴阳平衡
巨噬细胞极化
慢性阻塞性肺疾病
免疫炎症
Yin-Yang balance
macrophage polarization
chronic obstructive pulmonary disease
immunoinflammation
