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乳腺癌转移性腹腔积液11例临床病理学分析

Clinicopathological analysis of 11 cases of metastatic peritoneal effusion from breast cancer
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摘要 目的 探讨乳腺癌转移性腹腔积液的临床表现、病理特征、免疫表型、鉴别诊断及治疗预后。方法 回顾性分析11例乳腺癌发生腹腔积液转移的临床病理学资料,采用免疫组化EnVision两步法检测ER、PR、HER2、CATA-3等乳腺癌相关抗体的表达,分析其临床病理特征,并复习相关文献。结果 11例患者均为女性,平均年龄约54岁(41~68岁),均有乳腺癌病史,在治疗过程中发生腹腔积液转移,其中7例为浸润性导管癌,3例为浸润性小叶癌,1例为腺泡细胞癌,既往进行过手术、化疗、放疗、靶向治疗、免疫治疗或内分泌治疗等。免疫组化结果显示11例均为乳腺癌来源,分子分型5例为Luminal B型、5例为三阴型、1例为HER2过表达型。其中有3例腹腔积液的分子分型发生改变,例1由Luminal A型变为三阴型,例8及例10由Luminal B型变为三阴型。结论 乳腺癌发生腹腔积液转移罕见,提示预后不良,临床医师需及时提供相关病史,病理医师需要充分关注患者病史,并结合免疫组化进行鉴别,避免漏诊、误诊。
作者 齐贝贝 袁静萍 陈正卓 赵丽娜 Qi Beibei;Yuan Jingping;Chen Zhengzhuo;Zhao Lina(Department of Pathology,Renmin Hospital of Wuhan University,Wuhan 430060)
机构地区 武汉大学人民医院病理科
出处 《临床与实验病理学杂志》 北大核心 2025年第11期1516-1520,共5页 Chinese Journal of Clinical and Experimental Pathology
关键词 乳腺癌 腹腔积液 转移 免疫组织化学 临床病理特征 breast cancer abdominal fluid metastasis immunohistochemistry clinicopathological features
分类号 R737.9 [医药卫生—肿瘤]
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临床与实验病理学杂志
2025年 第11期

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