摘要
探究^(18)F-AV45正电子发射及X射线计算机断层成像系统(positron emission tomography/computed tomography,PET/CT)半定量分析对阿尔茨海默病(alzheimer disease,AD)的早期诊断价值。选取首都医科大学附属北京安贞医院南充医院2025年1月—2025年6月收入的60例疑似AD患者,对比^(18)F-AV45 PET/CT显像视觉分析与半定量分析对AD的诊断效能,并比较病理诊断阳性组与阴性组部分脑区标准摄取值比值(standardized uptake value ratio,SUVR)。结果显示,^(18)F-AV45 PET/CT视觉分析与半定量分析诊断结果与病理诊断结果的一致性尚可(Kappa=0.714、0.741,P<0.05),两种方法诊断AD的灵敏度、特异度、准确率比较,无统计学差异(P>0.05)。阳性组大脑双侧中央前回、额中回、前扣带和旁扣带回、海马、杏仁核、梭状回、顶上回、楔前叶、颞上回的SUVR均高于阴性组(P<0.05)。研究发现,^(18)F-AV45 PET/CT半定量分析对AD的诊断效能良好。
This study investigates the early diagnostic value of semi-quantitative analysis of^(18)F-AV45 positron emission tomography/computed tomography(PET/CT)for Alzheimer’s disease(AD).A total of 60 patients with suspected AD admitted to Nanchong Hospital of Beijing Anzhen Hospital Affiliated to Capital Medical University from January to June 2025 were selected,and the diagnostic efficacy of visual analysis and semi-quantitative analysis of^(18)F-AV45 PET/CT imaging for AD was compared.The standardized uptake value ratio(SUVR)of some brain regions in the positive and negative groups of pathological diagnosis was also compared.The results showed that the consistency between the diagnostic results of visual analysis and semi-quantitative analysis of^(18)F-AV45 PET/CT with pathological diagnosis was good(Kappa=0.714,0.741,P<0.05).There was no statistical difference between the two methods in sensitivity,specificity,and accuracy for diagnosing AD(P>0.05).The SUVR of the bilateral precentral gyrus,middle frontal gyrus,anterior cingulate and paracingulate gyri,hippocampus,amygdala,fusiform gyrus,superior parietal lobule,precuneus,and superior temporal gyrus in the positive group was higher than that in the negative group(P<0.05).The study found that semi-quantitative analysis of^(18)F-AV45 PET/CT has good diagnostic efficacy for AD.
作者
周小娇
ZHOU Xiaojiao(Department of Nuclear Medicine,Nanchong Hospital of Beijing Anzhen Hospital Affiliated to Capital Medical University,Nanchong Central Hospital,Nanchong,Sichuan 637000)
出处
《科技与健康》
2025年第20期49-52,共4页
Technology and Health
关键词
阿尔茨海默病
正电子发射断层成像
半定量分析
标准摄取值
Alzheimer’s disease
positron emission tomography
semi-quantitative analysis
standardized uptake value
