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重视阿尔茨海默病的痴呆前阶段 被引量：19

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摘要 随着人口老龄化进程的加速，阿尔茨海默病（Alzheimer’Sdisease，AD）患病人数逐年增加。流行病学研究显示，65岁以上老年人AD患病率在发达国家为4％～8％，我国为3％～7％。依此推算，我国目前有AD患者600万-800万。在过去的30多年中，全世界对AD研究投入了大量的科研力量，虽然发病机制的研究取得了很大进展，但是近年来针对AD发病机制不同靶点的新药临床试验屡屡失败，到目前为止仍然没有有效的、能阻止AD发生或延缓其进展的药物。究其原因，主要是目前研究仅仅针对AD痴呆阶段（dementiastage）患者，而在这一阶段神经元已经大量死亡，治疗已难以逆转疾病进程。因此，学者们逐渐认识到研究的重点应该转移到AD痴呆前阶段（pre—dementiastage）。
作者 贾建平 唐毅 王芬
机构地区 首都医科大学宣武医院神经科
出处 《中华神经科杂志》 CAS CSCD 北大核心 2013年第1期2-4,共3页 Chinese Journal of Neurology
关键词 阿尔茨海默病 痴呆 AD发病机制 AD患者 新药临床试验 人口老龄化 患病人数 流行病学
分类号 R749.16 [医药卫生—神经病学与精神病学]
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参考文献19

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二级参考文献164

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共引文献134

同被引文献126

引证文献19

二级引证文献268

中华神经科杂志
2013年 第1期

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