摘要
目的分析2型糖尿病(T2DM)合并白内障患者术后黄斑水肿(ME)危险因素,并构建预测模型。方法选取T2DM合并白内障患者98例,均行超声乳化人工晶状体植入术,根据术后ME情况分为ME组(47例)和无ME组(51例)。比较两组临床资料,采用Logistic回归分析术后发生ME的危险因素并构建其预测模型,通过ROC曲线评估危险因素及构建模型的预测效能。结果ME组视网膜病变占比、房水成纤维细胞生长因子(FGF)、单核细胞趋化因子-1(MCP-1)、转化生长因子-β2(TGF-β2)水平高于无ME组(P<0.05)。视网膜病变(X_(1))、房水FGF(X_(2))、MCP-1(X_(3))、TGF-β2(X_(4))升高是术后发生ME的独立危险因素(P<0.05),构建的预测模型为Logit(P)=4.216+0.392X_(1)+1.406X_(2)+1.263X_(3)+2.148X_(4)。ROC分析显示模型预测术后发生ME的AUC为0.962(95%CI:0.929~0.995),灵敏度为95.70%,特异度为84.32%。结论视网膜病变及房水FGF、MCP-1、TGF-β2升高是T2DM合并白内障患者术后发生ME的危险因素,据此构建的预测模型具有良好预测效能。
Aim To analyze risk factors for macular edema(ME)after cataract surgery in type 2 diabetes mellitus(T2DM)patients and construct a prediction model.Methods Ninety-eight T2DM patients with cataract who underwent phacoemulsification with intraocular lens implantation were divided into an ME group(47 cases)and a non-ME group(51 cases)according to postoperative ME occurrence.Clinical data were compared between the two groups.Logistic regression was used to identify risk factors and construct a prediction model.ROC curve was used to evaluate the predictive efficacy.Results The ME group had significantly higher proportions of retinopathy and higher aqueous levels of fibroblast growth factor(FGF),monocyte chemoattractant protein-1(MCP-1),and transforming growth factor-β2(TGF-β2)compared with the non-ME group(P<0.05).Retinopathy(X_(1))and elevated aqueous FGF(X_(2)),MCP-1(X_(3)),and TGF-β2(X_(4))were independent risk factors for postoperative ME(P<0.05).The prediction model was constructed according to the formula Logit(P)=4.216+0.392X_(1)+1.406X_(2)+1.263X_(3)+2.148X_(4).ROC analysis showed that the model had an AUC of 0.962(95%CI:0.929-0.995)with 95.70%sensitivity and 84.32%specificity,respectively.Conclusion Retinopathy and elevated aqueous FGF,MCP-1,and TGF-β2 are risk factors for postoperative ME in T2DM patients with cataract,and the constructed prediction model shows good predictive performance.
作者
夏洁
陈凡
蒋飞
潘善刚
陈蓓
吴华蓉
汪永
XIA Jie;CHEN Fan;JIANG Fei;PAN Shangang;CHEN Bei;WU Huarong;WANG Yong(Anhui Medical University,Hefei 230032,Anhui,China;Department of Ophthalmology,Lujiang County People's Hospital,Hefei 231500,Anhui,China;Department of Ophthalmology,Anqing Municipal Hospital,Anqing 246000,Anhui,China;Department of Ophthalmology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,Anhui,China)
出处
《中南医学科学杂志》
2025年第6期1023-1026,共4页
Medical Science Journal of Central South China
基金
安徽省第六批卫生健康适宜技术推广项目(SYJS202105)。
关键词
2型糖尿病
白内障
黄斑水肿
危险因素
预测模型
type 2 diabetes mellitus
cataract
macular edema
risk factors
prediction model
