摘要
目的:基于数据挖掘与整合药理学分析名中医柯干治疗脾虚气滞型胃脘痛的用药规律。方法:收集2017年9月—2021年9月在浙江省台州医院名中医柯干门诊诊治的脾气滞型胃脘痛医案。借助中医传承计算平台V3.5软件,运用软件中“数据分析”模块的“统计分析”“方剂分析”“症状分析”功能对纳入的医案进行症状及其组方规律分析,将所得结果进行网络可视化展示;针对不同证候人群,以药物频次、核心药物组合通过中医药整合药理学研究平台(TCMIP)V2.0进行整合药理学分析组合,确定潜在规律方。结果:共收集医案500例,涉及中药67味。①证候关联。脾虚气滞型胃脘痛(500例)与肝脾失调病机高度相关,女性占比更高(353/500),与情志因素(如肝郁)密切相关。②用药规律。使用频次前3位分别为茯苓(411次)、佛手(383次)、海螵蛸(381次);药物四气以温性为主,五味以苦味最多,归经以脾经为首。③治法特点。疏肝健脾法(500次)为主导,辅以理气(1236次)、补虚(855次)等,体现肝脾同调思路。④药理机制。高频组合(如茯苓-佛手)通过调节胃蛋白酶、5-羟色胺等靶点,发挥抗炎、抗溃疡及镇静作用。结论:名中医柯干治疗脾虚气滞型胃脘痛潜在规律方主要包括茯苓、海螵蛸、浙贝母、佛手、玫瑰花、梅花、党参、炒白芍、炒白术、延胡索、炙甘草、陈皮。
Objective:To analyze the medication rules of the renowned traditional Chinese medicine(TCM)practitioner KE Gan in treating epigastric pain of spleen deficiency and qi stagnation type based on data mining and integrative pharmacology.Methods:Medical records of patients with epigastric pain of spleen deficiency and qi stagnation type treated at the outpatient clinic of the renowned TCM practitioner KE Gan in Taizhou Hospital of Zhejiang Province,from September 2017 to September 2021 were collected.Using the Traditional Chinese Medicine Inheritance Computing System(TCMICS)V3.5 software,the"statistical analysis","prescription analysis",and"symptom analysis"functions of the"data analysis"module were employed to analyze the symptoms and prescription patterns of the included medical records.The results were visually displayed through network visualization.For patients with epigastric pain of various syndromes,integrative pharmacological analysis of drug combinations was conducted using the Integrative Pharmacology-Based Research Platform of Traditional Chinese Medicine(TCMIP)V2.0 platform,based on drug frequency and core drug combinations,to identify potential regular prescriptions.Results:A total of 500 medical records were collected,involving 67 Chinese herbal medicines.①Syndrome correlation:Epigastric pain of spleen deficiency and qi stagnation type(500 cases)was highly correlated with the pathogenesis of liver-spleen disharmony,with a higher proportion of female patients(353/500),and was closely related to emotional factors(such as liver depression).②Medication rules:The top three most frequently used Chinese herbal medicines were Poria(411 times),Citri Sarcodactylis Fructus(383 times),and Endoconcha Sepiae(381 times).The four properties of Chinese herbal medicine were predominantly warm,the five flavors were mostly bitter,and the meridian tropism was primarily the spleen meridian.③Treatment characteristics:The method of soothing the liver and strengthening the spleen(500 times)was dominant,supplemented by regulating qi(1236 times)and tonifying deficiency(855 times),reflecting the approach of simultaneously regulating the liver and spleen.④Pharmacological mechanisms:High-frequency drug combinations(e.g.,Poria-Citri Sarcodactylis Fructus)exert anti-inflammatory,anti-ulcer,and sedative effects by regulating targets such as pepsin and serotonin.Conclusion:The potential regular prescriptions of the renowned TCM practitioner KE Gan for treating epigastric pain of spleen deficiency and qi stagnation type mainly include Poria,Endoconcha Sepiae,Fritillariae Thunbergii Bulbus,Citri Sarcodactylis Fructus,Rosae Rugosae Flos,Mume Flos,Codonopsis Radix,stir-fried Paeoniae Radix Alba,stir-fried Atractylodis Macrocephalae Rhizoma,Corydalis Rhizoma,Glycyrrhizae Radix et Rhizoma Praeparata cum Melle,and Citri Reticulatae Pericarpium.
作者
宋聪琳
SONG Conglin(Taizhou Hospital of Zhejiang Province,Taizhou Zhejiang 317000,China)
出处
《新中医》
2025年第22期8-13,共6页
New Chinese Medicine
基金
浙江省中医药科技计划项目(2023ZF056)。
关键词
胃脘痛
脾虚气滞型
数据挖掘
整合药理学
用药规律
柯干
Epigastric pain
Spleen deficiency and qi stagnation type
Data mining
Integrative pharmacology
Medication rules
KE Gan
