摘要
目的:利用数据挖掘方法,探析中医药治疗转移性乳腺癌(metastatic breast cancer,mBC)的用药规律及病机治法特点。方法:检索2000年1月至2021年9月数据库中有关中医药治疗mBC的文献,运用中医传承辅助系统平台(V2.5)对中药复方进行频次统计、关联规则和聚类分析,研究中医药治疗mBC用药规律并探讨其病机治法。结果:经筛选后,纳入108首中药复方,涉及210味中药。高频药物有白术、黄芪、茯苓、熟地黄、白花蛇舌草、山慈菇、白芍、党参、当归、莪术、补骨脂等,药类多为补虚药、活血化瘀药、利水渗湿药及清热药四大类,药性以甘温为主,归经以肝脾肾经为主。出现频次最高的药对是“白术-茯苓”。挖掘出6组核心药物配伍及3个新方组合。结论:mBC多属本虚标实之证,病机多为肝、脾、肾三脏失调,中医药治疗mBC以“扶正-活血-解毒”为主轴,辨证采用补气活血、补肾健脾、清热解毒为主线的治法,随证加减。
Objective:To explore the medication rules,the pathogenesis and therapeutic methods of metastatic breast cancer using data mining methods.Methods:The literature on TCM therapies of metastatic breast cancer were retrieved from January,2000 to September,2021,Traditional Chinese Medicine Inheritance Support System(TCMISS)was applied to perform frequency statistics,association rules and cluster analysis of herbal compounds,to study the medication rules of TCM therapy for the disease,and to discuss the pathogenesis and therapeutic methods of the diseases.Results:A total of 108 herbal compounds were included by screening,involving 210 herbs.High-frequency medicines contained Baizhu(Atractylodes macrocephala Koidz.),Huangqi(Astragali radix),Fuling[Poria cocos(Schw.)Wol],Shudihuang(Rehmanniae radix praeparata),Baihuasheshecao(Hedyotis diffusa),and Shancigu(Cremastrae pseudobulbus pleiones pseudobulbs),Baishao(Paeoniae radix alba),Dangshen(Codonopsis radix),Danggui(Angelicae sinensis radix),Ezhu(Curcumae rhizoma)as well as Buguzhi(Psoraleae fructus),most of them were the categories of replenishing the deficiency,activating blood and resolving the stagnation,promoting diuresis and clearing dampness,and heat-clearing,of sweet flavor and warm nature,entering the meridians of liver,spleen and kidney.The drug combination with the highest frequencies contained"Baizhu-Fuling".The study has yielded six core drug compatibility and three new combinations.Conclusion:TCM therapy for metastatic breast cancer chooses"enhancing healthy Qi-activating blood-detoxifying"as the main axis because of its pattern of asthenia in origin and asthenia in superficiality,and its pathogenesis of the dysfunction of liver,spleen and kidney,adopting replenishing Qi and activating blood,invigorating kidney and spleen,clearing-heat and detoxifying as the main line of therapeutic methods,modifying according to the accompanying symptoms.
作者
谢婷
胡金辉
李杰
杨争
吴泳蓉
袁博
龙红萍
李萍
XIE Ting;HU Jinhui;LI Jie;YANG Zheng;WU Yongrong;YUAN Bo;LONG Hongping;LI Ping(Hunan University of Chinese Medicine,Changsha 410208,China;The First Hospital of Hunan University of Chinese Medicine,Changsha 410007,China)
出处
《西部中医药》
2025年第7期67-71,共5页
Western Journal of Traditional Chinese Medicine
关键词
转移性乳腺癌
用药规律
病机治法
数据挖掘
metastatic breast cancer
medication rules
the pathogenesis and therapeutic methods
data mining
