摘要
目的:探讨喉鳞状细胞癌(LSCC)组织中细胞型纤维肉瘤原癌基因(C-FOS)、基质金属蛋白酶-11(MMP-11)表达,并分析其与病人预后相关性。方法:选择LSCC病人98例,取肿瘤组织(LSCC组)和癌旁组织(癌旁组),并选取30例正常黏膜组织作为对照(对照组)。比较3组C-FOS、MMP-11表达情况,分析C-FOS、MMP-11阳性表达与LSCC临床特征相关性及其对LSCC复发的预测价值。结果:LSCC组、癌旁组和对照组C-FOS、MMP-11表达阳性率间差异均有统计学意义(P<0.01)。不同TNM分期、组织学分级和淋巴结转移情况的LSCC病人C-FOS、MMP-11表达阳性率差异均有统计学意义(P<0.05~P<0.01)。随访12个月,复发组LSCC病人MMP-11表达阳性率与未复发组差异有统计学意义(P<0.05)。ROC曲线分析显示,C-FOS、MMP-11及二者联合预测LSCC复发AUC分别为0.631、0.613、0.656。结论:LSCC病人C-FOS和MMP-11表达阳性率升高,且阳性率与病人TNM分期、分化程度及淋巴结转移相关,C-FOS和MMP-11对LSCC病人复发有一定预测价值。
Objective:To investigate the expression of proto-oncogene protein cellular fibrosarcoma oncogene(C-FOS)and matrix metalloproteinase-11(MMP-11)in laryngeal squamous cell carcinoma(LSCC)tissues and their correlation with patients'prognosis.Methods:A total of 98 LSCC patients were selected,and samples were collected from tumor tissues(LSCC group)and adjacent cancer tissues(para-carcinoma group).Additionally,30 cases of normal mucosa tissues were selected as controls(control group).The expression of C-FOS and MMP-11 was compared among the three groups,and the correlation between positive expression of CFOS and MMP-11 with LSCC clinical characteristics and their predictive value for LSCC recurrence was analyzed.Results:Statistically significant differences were observed in the positive expression rates of C-FOS and MMP-11 among the LSCC group,paracarcinoma group,and control group(P<0.01).The positive expression rates of C-FOS and MMP-11 showed statistically significant differences among LSCC patients with different TNM stages,histological grades,and lymph node metastasis status(P<0.05 to P<0.01).After 12 months of follow-up,there was a statistically significant difference in the positive expression rate of MMP-11 between the recurrence group and non-recurrence group of LSCC patients(P<0.05).ROC curve analysis showed that the AUC values for predicting LSCC recurrence were 0.631,0.613,and 0.656 for C-FOS,MMP-11,and their combination,respectively.Conclusions:The positive expression rates of C-FOS and MMP-11 are elevated in LSCC patients and are correlated with TNM stage,differentiation degree,and lymph node metastasis.C-FOS and MMP-11 have certain predictive value for recurrence in LSCC patients.
作者
张继友
许超
姚勇
常艺琼
ZHANG Jiyou;XU Chao;YAO Yong;CHANG Yiqiong(Department of Otolaryngology,First People's Hospital of Guangyuan,Guangyuan Sichuan 628000,China)
出处
《蚌埠医科大学学报》
2025年第10期1430-1433,1438,共5页
Journal of Bengbu Medical University
基金
四川省科技计划资助项目(2021YFS0225)。
关键词
喉鳞状细胞癌
细胞型纤维肉瘤原癌基因
基质金属蛋白酶-11
术后复发
laryngeal squamous cell carcinoma
cellular fibrosarcoma oncogene
matrix metalloproteinase-11
postoperative recurrence
