摘要
目的观察腔镜手术治疗乳腺癌疗效观察及对血清基质金属蛋白酶-11(MMP-11)、转录因子Sp1和金属蛋白酶组织抑制因子-1(TIMP-1)的影响。方法选取2024年1月至2025年2月于武汉市中心医院就诊的乳腺癌女性患者60例作为研究对象(年龄<60周岁),根据患者所采用的术式将上述患者分为对照组和观察组,每组30例,对照组患者接受传统的乳腺单纯切除术,研究组患者接受腔镜下皮下腺体切除及假体植入,记录并比较两组患者的手术时间、术中出血量、术后引流量以及住院时间、治疗满意度,治疗前后血清MMP-11、Sp1和TIMP-1水平和生命质量评分(QOL),组间比较采用t检验。结果观察组患者的术后引流量[(270±6)ml]以及住院时间[(8±4)d]均低于对照组[(380±10)ml、(11±3)d,t=10.757、3.286,P<0.05],观察组术中出血量[(32±3)ml]低于对照组[(47±8)ml,t=14.458,P<0.05],观察组患者的满意度(93.33%)高于对照组(80.00%,χ^(2)=4.200,P<0.05)。治疗后观察组患者血清的MMP-11[(1.59±0.35)μg/ml]、Sp1[(2.13±0.38)μg/ml]和TIMP-1[(0.87±0.24)μg/ml]水平均低于对照组[(2.11±0.46)、(2.67±0.43)、(1.28±0.29)μg/ml,t=4.927、5.154、5.966,P<0.05),而患者身体状况[(81.52±9.31)分]、行为[(82.45±7.31)分]、自评生活质量[(90.81±9.22)分]和运动功能评分[(89.82±7.28)分]均高于对照组[(72.18±8.41)分、(72.61±7.41)分、(81.25±9.22)分、(81.28±7.21)分,t=4.078、5.178、4.016、4.565,P<0.05]。结论腔镜手术不仅能够减少术中出血量及术后引流量,促进患者术后恢复,还能提高治疗满意度和患者的生活质量。
Objective To observe the efficacy of laparoscopic surgery for the treatment of breast cancer and its effects on serum matrix metalloproteinase-11(MMP-11),Sp1,and tissue inhibitors of metalloproteinase-1(TIMP-1).Methods Totally,60 cases of breast cancer(female,age<60)who received treatment at Wuhan Central Hospital from January 2024 to February 2025 were selected as study subjects.Based on the surgical methods employed,these patients were divided into a control group and a study group(n=30).Patients in the control group underwent traditional simple mastectomy,while patients in the study group received endoscopic subcutaneous gland resection and prosthesis implantation.The surgical time,intraoperative blood loss,postoperative drainage volume,length of hospital stay,treatment satisfaction,serum levels of MMP-11,Sp1,and TIMP-1 before and after treatment,as well as quality of life scores(QOL)were recorded and compared between the two groups.The t test was adopted for comparison Results Postoperative drainage volume[(270±6)ml],and hospital stay[(8±4)d]in the study group were significantly reduced as compared with those in the control group[(380±10)ml,(11±3)d,t=10.757,3.286,P<0.05].The intraoperative blood loss was also significantly less in the study group[(32±3)ml]than in the control group[(47±8)ml,t=14.458,P<0.05].The patient satisfaction rate in the study group(93.33%)was significantly higher than that in the control group(80.00%,χ^(2)=4.200,P<0.05).After treatment,the serum levels of MMP-11[(1.59±0.35)μg/ml],Sp1[(2.13±0.38)μg/ml],and TIMP-1[(0.87±0.24)μg/ml]in the study group were significantly reduced when compared with the control group[(2.11±0.46),(2.67±0.43),(1.28±0.29)μg/ml,t=4.927,5.154,5.966,P<0.05].Additionally,scores related to physical status[(81.52±9.31)points],behavior[(82.45±7.31)points],self-rated quality of life[(90.81±9.22)points],and intestinal function[(89.82±7.28)points]were all higher in the study group than in the control group[(72.18±8.41),(72.61±7.41),(81.25±9.22),(81.28±7.21)points,t=4.078,5.178,4.016,4.565,P<0.05].Conclusion Laparoscopic surgery not only reduces intraoperative blood loss and postoperative drainage volume,promotes postoperative recovery,but also enhances treatment satisfaction and improves the quality of life for patients.
作者
张家铭
黄志勇
江明
扬帆
Zhang Jiaming;Huang Zhiyong;Jiang Ming;Yang Fan(Department of Thyroid and Breast Surgery,Wuhan Central Hospital,Wuhan 430014,China;Department of Laboratory Medicine,Wuhan Central Hospital,Wuhan 430014,China)
出处
《中华实验外科杂志》
2025年第7期1345-1348,共4页
Chinese Journal of Experimental Surgery
基金
中国医药卫生事业发展基金会医药科研课题资助项目(chmdf2024-xrzx10-12)。
