摘要
目的探讨青岛市甘油三酯葡萄糖指数(TyG)–肥胖联合指数与高尿酸血症(HUA)发病风险的关联,以期为预防与管理HUA提供科学依据。方法采用前瞻性队列研究,选取2006—2009年参与青岛市糖尿病预防项目并于2012—2015年、2019—2023年完成随访的3294名成年人作为研究对象。采用Cox比例风险回归分析基线TyG–体质量指数(TyG-BMI)、TyG–腰围指数(TyG-WC)不同水平组与HUA发病风险的关联,采用限制性立方样条图分析基线TyG-BMI、TyG-WC指数与HUA发病风险的剂量–反应关系,根据性别、年龄等协变量进行亚组分析,并分析其与TyG–肥胖联合指数的交互作用。结果HUA发病430例,新发HAU累计发病率13.1%。多因素Cox回归分析显示,基线TyG-BMI、TyG-WC指数的Q4水平组较Q1组HUA的发病风险分别增加48%(HR=1.48,95%CI=1.10~1.99)和46%(HR=1.46,95%CI=1.08~1.99)。限制性立方样条图显示,基线TyG-BMI(P_(整体)<0.001,P_(非线性)=0.639)、TyG-WC(P_(整体)<0.001,P_(非线性)=0.776)指数与HUA发病风险均呈线性剂量关系。女性、农村、高血压病人群Q4组基线TyG–肥胖联合指数的HUA发病风险关联分别高于男性、城市、非高血压(均P<0.05),各亚组均不存在交互作用(均P>0.05)。结论基线TyG-BMI和TyG-WC指数升高均与HUA发病风险增加相关,且在女性、农村及高血压人群中更为显著。
Objective To explore the associations between triglyceride glucose(TyG)-obesity composite indices and the risk of hyperuricemia(HUA)in Qingdao,China,providing a basis for the prevention and management of HUA.Methods A prospective cohort study was conducted,encompassing a total of 3294 adults recruited in the baseline survey from 2006 to 2009 and participating the follow-up survey from 2012 to 2015 and 2019 to 2023.Cox proportional hazards regression was adopted to analyze the associations of baseline TyG-body mass index(TyG-BMI)and TyG-waist circumference(TyG-WC)with the risk of HUA.The restricted cubic spline method was used to analyze the doseresponse relationships of baseline TyG-BMI and TyG-WC with the risk of HUA.Subgroup analyses were performed based on covariates such as gender and age,and their interactions with the TyG-obesity composite indices were analyzed.Results A total of 430(13.1%)adults were identified with HUA.Multivariate Cox regression analysis showed that the highest quartiles of baseline TyG-BMI and TyG-WC increased the risk of HUA by 48%(HR=1.48,95% CI:1.10-1.99)and 46%(HR=1.46,95%CI:1.08-1.99)compared with the lowest quartiles.Restricted cubic splines indicated linear dose-response relationships of baseline TyG-BMI(P_(overall)<0.001,P_(non-linear)=0.639)and TyG-WC(P_(overall)<0.001,P_(non-linear)=0.776)with the risk of HUA.Subgroup analyses showed that the highest quartiles of baseline TyG-obesity composite indices in females,rural adults,and hypertension adults were higher than those in males,urban adults,and non-hypertension adults(all P<0.05).No significant interactions were observed with TyG-obesity composite indices(all P>0.05).Conclusion Elevated baseline levels of TyG-BMI and TyG-WC are associated with an increased risk of HUA particularly among females,rural adults,and hypertension adults.
作者
吴浩佳
孙健
叶美怡
王治
郭宝柱
崔静
孙健平
WU Haojia;SUN Jian;YE Meiyi;WANG Zhi;GUO Baozhu;CUI Jing;SUN Jianping(School of Public Health,Shandong Second Medical University,Weifang 261053,China;Department of Urology,Qingdao Women and Children's Hospital,Qingdao 266000,China;College of Humanities and Social Sciences,Dalian Medical University,Dalian 116000,China;Qingdao Center for Disease Control and Prevention/Qingdao Institute of Preventive Medicine,Qingdao 266000,China)
出处
《中国公共卫生》
北大核心
2025年第10期1168-1175,共8页
Chinese Journal of Public Health
基金
青岛市民生科技计划项目(19-6-1-5-nsh)。
