摘要
目的 探讨急性胰腺炎(AP)患者应用生长抑素联合多学科协同按需干预的临床效果。方法 选取杭州市第一人民医院消化科2020年1月至2025年1月收治的AP患者,分为对照组(生长抑素联合常规干预)和观察组(生长抑素联合多学科协同按需干预),比较两组患者的临床疗效、胰腺损伤标志物[血清淀粉酶(AMY)、脂肪酶(LPS)]、炎症相关指标[白细胞介素-18(IL-18)、白细胞介素-6(IL-6)、C反应蛋白(CRP)]、器官功能指标[血尿素氮(BUN)、肌酐(Cr)、总胆红素、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、血乳酸(Lac)]、AP相关并发症和药物不良反应。结果 共纳入120例AP患者,每组各60例。治疗后,观察组临床总有效率高于对照组(93.33%vs.80.00%,P<0.05);两组AMY、LPS、IL-18、IL-6、CRP、BUN、Cr、总胆红素、ALT、AST、Lac均较治疗前下降(P<0.05),且观察组低于对照组(P<0.05);两组AP相关并发症、药物不良反应发生率比较差异无统计学意义(P>0.05)。结论 生长抑素联合多学科协同按需干预治疗AP有显著的临床疗效,可减轻胰腺损伤和炎症反应,并能改善器官功能。
Objective To investigate the clinical effect of the combination of somatostatin and multidisciplinary collaborative on-demand intervention on patients with acute pancreatitis(AP).Methods AP patients admitted to department of gastroenterology of Hangzhou First People’s Hospital were selected from January 2020 to January 2025,and were categorized into the control group(somatostatin combined with routine intervention)and the observation group(somatostatin combined with multidisciplinary collaborative on-demand intervention).The clinical efficacy,pancreatic injury markers[serum amylase(AMY),lipase(LPS)],inflammation-related indicators[interleukin-18(IL-18),interleukin-6(IL-6),C-reactive protein(CRP)],organ function indicators[blood urea nitrogen(BUN),creatinine(Cr),total bilirubin,alanine aminotransferase(ALT),aspartate aminotransferase(AST),blood lactic acid(Lac)],AP-related complications and adverse drug reactions were compared between both groups.Results A total of 120 AP patients were included,with 60 patients in each group.After treatment,the total clinical effective rate in the observation group was higher compared to the control group(93.33%vs.80.00%,P<0.05).The levels of AMY,LPS,IL-18,IL-6,CRP,BUN,Cr,total bilirubin,ALT,AST and Lac in the two groups were decreased compared with those before treatment(P<0.05),and the observation group had lower levels(P<0.05).The incidence rates of AP-related complications and adverse drug reactions exhibited no significant differences between the two groups(P>0.05).Conclusion Somatostatin combined with multidisciplinary collaborative on-demand intervention has significant clinical efficacy in the treatment of AP.Additionally,it can relieve the pancreatic injury and inflammatory response,and improve the organ function.
作者
徐丽红
何梦晴
夏肖枫
楼立兰
范震
XU Lihong;HE Mengqing;XIA Xiaofeng;LOU Lilan;FAN Zhen(Department of Gastroenterology,Affiliated Hangzhou First People's Hospital,School of Medicine,West Lake University,Hangzhou 310000,China)
出处
《药学前沿》
2025年第10期1695-1701,共7页
China Pharmacist
基金
杭州市医药卫生科技项目(ZD20240015)。
关键词
急性胰腺炎
生长抑素
多学科协同按需干预
胰腺损伤标志物
生活质量
Acute pancreatitis
Somatostatin
Multidisciplinary collaborative on-demand intervention
Pancreatic injury markers
Quality of life
