摘要
目的分析河北地区献血者人群HCV感染变化趋势和人群分布特征,为采供血机构策略流程调整等提供数据支持。方法收集河北省12家血站2012—2021年的相关数据,分析抗-HCV双试剂反应率变化以及献血者不同类别、性别和出生年月队列中分布特征。结果2012—2021年河北省12家血站共检测745.76万人份标本,其中来自初次献血者346.59万份(46.47%),来自重复献血者399.17万份(53.53%)。抗-HCV双试剂反应性标本7167份(9.61/万)。抗-HCV双试剂反应率呈逐年下降趋势(P<0.05),从最初的17.40/万下降至期末的4.95/万,自2017年以后重复献血者抗-HCV双试剂反应率已低至1/万以下。抗-HCV双试剂反应率初次献血者(19.42/万)高于重复献血者(1.09/万)(P<0.05),女性初次献血者(20.98/万)高于男性初次献血者(18.49/万)(P<0.05)。初次献血者的抗-HCV双试剂反应率在1976年前出生年龄段和1989—1994出生年龄段出现2个高峰,且2个高峰存在性别差异。主高峰1976年前出生的女性献血者抗-HCV双试剂反应率(52.22/万)比男性(32.28/万)高(P<0.05),而次高峰1989—1994年出生男性献血者抗-HCV双试剂反应率(25.75/万)比女性(14.28/万)高(P<0.05)。结论河北地区献血人群HCV感染呈逐年下降趋势,绝大部分感染者集中在1995年前出生的初次献血人群中。趋势和特征分析的结果可以作为采血前初筛策略制订、血筛核酸检测数据分析、血筛检测流程调整以及作为消除丙型肝炎公共卫生危害行动工作有效筛查重点人群的依据。
Objective To analyze the changing trend and distribution characteristics of hepatitis C virus(HCV)infection among blood donors in Hebei,thereby providing data to support strategy and procedure adjustment for blood collection and supply institutions.Methods Data from 12 blood stations in Hebei Province from 2012 to 2021 were collected.These data were analyzed to determine trends in anti-HCV antibody double reagent reactive rate and to characterize its distribution among different donor categories,genders and birth cohorts.Results During the period from 2012 to 2021,a total of 7.4576 million samples were tested at 12 blood stations in Hebei Province,with 3.4659 million(46.47%)from first-time donors,and 3.9917 million(53.53%)from repeat donors.The number(of anti-HCV double reagent reactive samples was 7167(9.61/10000).The anti-HCV double reagent reactive rate showed a annual downward trend(P<0.05),from 17.40/10000 at the beginning to 4.95/10000 at the end of the study period.Additionally,the double reagent reactive rate of repeat blood donors had remained below 1/10000 since 2017.The double reagent reactive rate of first-time blood donors(19.42/10000)was higher than in repeat donors(1.09/10000)(P<0.05),and the double-reagent reactive rate of female first-time blood donors(20.98/10000)was higher than that of male first-time blood donors(18.49/10000)(P<0.05).The anti-HCV double reagent reactive rate among first-time donors exhibited two distinct peaks within the pre-1976 and 1989-1994 birth cohorts,with notable gender differences observed in both peak periods.The rate of double reagent reactive in females born before 1976(52.22/10000)was higher than that in males(32.28/10000)(P<0.05),while that of males born in 1989-1994 was higher(25.75/10000)than that of females(14.28/10000)(P<0.05).Conclusion The prevalenc of HCV infection among blood donors in Hebei Province has shown a consistent year-over-year decline over the study period.The majority of infected individuals are found among the first-time blood donors born before 1995.These trends and characteristics provide valuable insights for developing pre-blood collection screening strategies,analyzing nucleic acid test data in blood screening,adjusting blood screening procedures,and provide evidence for targeted screening of highrisk populations as part of public health initiatives to eliminate hepatitis C.
作者
韩卫
张慧贤
王艳彬
赵雅姿
韩雪峰
唐昆
康洁
HAN Wei;ZHANG Huixian;WANG Yanbin;ZHAO Yazi;HAN Xuefeng;TANG Kun;KANG Jie(Heibei Province Blood Center,Shijiazhuang 050071,China)
出处
《中国输血杂志》
2025年第10期1355-1360,共6页
Chinese Journal of Blood Transfusion
基金
河北省卫生健康委员会指令性课题(20180934)。
关键词
HCV/感染
初次/重复献血者
采血前初筛
HCV/infection
first-time/repeat blood donors
pre-blood collection screening
