摘要
雄激素是人体重要的类固醇激素,影响男性生殖健康;胃肠动力是消化系统完成其生理功能的重要组成部分。赵家有团队受中医脾(胃)肾关系启发,根据研究阶段性成果,结合同行研究前沿,凝练提出“睾-肠-生殖轴”,雄激素与胃肠动力的关系是该轴的重要内涵之一。本文以该轴为指引,梳理雄激素与胃肠动力关系的研究进展,雄激素通过胃肠道机械运动、平滑肌收缩、胃肠神经功能、胃肠激素分泌、肠道菌群结构和Cajal间质细胞等影响胃肠动力,异常时可导致肠易激综合征、功能性消化不良、慢性便秘及胃食管反流病等疾病。
Androgens,as crucial steroid hormones in human body,significantly impact male reproductive health,while gastrointestinal motility is an important component for the digestive system to perform its physiological functions.Inspired by the spleen(stomach)-kidney relationship theory in traditional Chinese medicine,Zhao Jiayou′s team has concisely proposed the"testis-gut-reproduction axis",based on the research′s phased results and in combination with the forefront of peer studies.The interplay between androgens and gastrointestinal motility is a core aspect of this axis.This paper takes this axis as a guide to review the research progress on the relationship between androgens and gastrointestinal motility.Androgens influence gastrointestinal motility through gastrointestinal mechanical movement,smooth muscle contraction,gastrointestinal nerve function,gastrointestinal hormone secretion,intestinal microbiota structure,and interstitial cells of Cajal.When androgens are abnormal,it can lead to irritable bowel syndrome,functional dyspepsia,chronic constipation,gastroesophageal reflux and other diseases.
作者
徐浩然
曹芮
陈文康
邹和德
赵家有
XU Haoran;CAO Rui;CHEN Wenkang;ZOU Hede;ZHAO Jiayou(Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;School of Hebei University of Chinese Medicine,Shijiazhuang 050091,Hebei,China;School of China Academy of Chinese Medical Sciences,Beijing 100700,China)
出处
《中国性科学》
2025年第10期11-14,共4页
Chinese Journal of Human Sexuality
基金
国家自然科学基金项目(82274337,82574855)
中国中医科学院科技创新工程课题资助项目(CI2023C018YL,CI2023E002T-17)。
关键词
雄激素
胃肠动力
“睾-肠-生殖轴”
研究进展
Androgens
Gastrointestinal motility
"Testis-gut-reproduction axis"
Research progress
