摘要
胃肠道间质瘤（GIST）是起源于间叶组织的肿瘤，其特异性的存在c-kit及血小板源性生长因子受体-α（PDGFRA）基因突变。大多数GIST都具有恶性倾向。肿瘤体积、核分裂象作为评估肿瘤预后的两大基本因素，在很大程度上取决于肿瘤的部位。在分子生物学方面，c-kit基因主要突变位点为外显子11、9、13、17；PDGFRA基因突变位点则为外显子18、12、14。不同突变位点及不同突变类型与肿瘤良恶性预后有着密切关系。免疫组化、组织学同样是判断GIST预后两大重要因素。
Gastrointestinal stromal tumor（GIST） is the most common form of mesenchymal tumor of the gastrointestinal tract. Most GISTs characteristically harbor activating mutations of c-kit or PDGFRA（ platelet derived growth factor receptor alpha, PDGFRA）. All GISTs should be regarded having malignant potential. Tumor size and mitotic count, as two basic progonstic factors for primary GISTs, are largely site dependent. Most c-kit mutations have been found in exon 11,9,13,17 while PDGFRA mutations re found in exon 18,12,14.The sites and types of mutions are associated with the prognosis of GIST. Histopathology and immunohistochemistry are another two factors predicting tumor outcome.
出处
《国际肿瘤学杂志》
CAS
2011年第5期380-384,共5页
Journal of International Oncology
关键词
胃肠道间质瘤
基因
突变
免疫组织化学
组织学
Gastrointestinal stromal tumors
Gene
Mutation
Immunohistochemistry
Histology
