摘要
目的:观察小柴胡汤加减联合阿奇霉素治疗肺炎支原体肺炎患儿的效果。方法:选取2023年1月至2024年1月该院收治的120例肺炎支原体肺炎患儿进行前瞻性研究,按照随机信封法将其分为研究组与对照组各60例。对照组采用阿奇霉素治疗,研究组在对照组基础上联合小柴胡汤加减治疗。比较两组临床疗效、临床症状(咳嗽、肺啰音、发热)消失时间,治疗前后肺功能指标[用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))]水平、血气指标[动脉血氧饱和度(SaO_(2))、动脉血氧分压(PaO_(2))]水平、炎性指标[C反应蛋白(CRP)、白细胞计数(WBC)]水平、中医证候积分(高热不退、咳嗽、痰黄黏稠),以及不良反应发生率。结果:研究组治疗总有效率为96.67%(58/60),高于对照组的85.00%(51/60),差异有统计学意义(P<0.05);研究组咳嗽、肺啰音、发热等临床症状消失时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组FVC、FEV_(1)、SaO_(2)、PaO_(2)水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);治疗后,两组CRP、WBC水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组高热不退、咳嗽、痰黄黏稠等中医证候积分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:小柴胡汤加减联合阿奇霉素治疗肺炎支原体肺炎患儿可提高治疗总有效率、肺功能指标和血气指标水平,以及降低炎性指标水平和中医证候积分,效果优于单纯阿奇霉素治疗。
Objective:To observe effects of Xiaochaihu decoction combined with Azithromycin in treatment of children with mycoplasma pneumonia.Methods:A prospective study was conducted on 120 children with mycoplasma pneumonia admitted to the hospital from January 2023 to January 2024.According to the random envelope method,they were divided into study group and control group,60 cases in each group.The control group was treated with Azithromycin,while the study group was treated with Xiaochaihu decoction on the basis of that of the control group.The clinical efficacy,the disappearance time of clinical symptoms(cough,pulmonary rales,fever),the levels of lung function indexes[forced vital capacity(FVC),forced expiratory volume in one second(FEV_(1))],blood gas indexes[arterial oxygen saturation(SaO_(2)),arterial oxygen partial pressure(PaO_(2))],inflammatory indexes[C-reactive protein(CRP),white blood cell count(WBC)],the traditional Chinese medicine(TCM)syndrome scores(continuing high fever,cough,yellow and sticky phlegm)before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 96.67%(58/60),which was higher than 85.00%(51/60)in the control group,and the difference was statistically significant(P<0.05).The disappearance time of clinical symptoms such as cough,lung rales,and fever in the research group was shorter than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of FVC,FEV_(1),SaO_(2)and PaO_(2)in the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CRP and WBC in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the scores of TCM syndromes such as continuing high fever,cough,yellow and sticky phlegm in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Xiaochaihu decoction combined with Azithromycin in the treatment of the children with mycoplasma pneumonia can improve the total effective rate of treatment and the levels of lung function indexes and blood gas indexes,and reduce the levels of inflammatory indexes and the TCM syndrome scores.Moreover,it is superior to simple Azithromycin treatment.
作者
赵敏
代杰
ZHAO Min;DAI Jie(Kaifeng Children’s Hospital,Department of Pharmacy,Kaifeng 475000 Henan,China;Kaifeng Children’s Hospital,Digestive Department,Kaifeng 475000 Henan,China)
出处
《中国民康医学》
2025年第20期118-121,共4页
Medical Journal of Chinese People’s Health
关键词
小柴胡汤
阿奇霉素
支原体感染肺炎
儿童
肺功能
中医证候
Xiaochaihu decoction
Azithromycin
Mycoplasma pneumonia
Children
Lung function
TCM syndrome
