摘要
目的分析重度高甘油三酯血症(HTG)人群发生高脂血症性胰腺炎(HLP)的影响因素,旨在为重度HTG人群的健康管理提供参考。方法收集331例参加健康体检的重度HTG患者作为研究对象,回顾性分析其基线特征;并根据有无HLP病史分为HLP组(n=31)和非HLP组(n=300)。比较两组临床资料;分析HLP发病的影响因素。结果HLP组合并糖尿病占比45.16%及甘油三酯(TG)(26.40±15.58)mmol/L、总胆固醇(TC)(9.13±3.87)mmol/L、空腹血糖(8.79±4.30)mmol/L均显著高于非HLP组的12.67%、(17.48±7.20)mmol/L、(6.99±2.03)mmol/L、(7.14±3.37)mmol/L(P<0.05);两组性别、年龄、体质量指数(BMI)、饮酒史、吸烟史、合并高血压情况比较无差异(P>0.05)。多因素Logistic回归分析显示,TG高、合并糖尿病是HLP发病的独立危险因素(P<0.05)。结论高TG水平、合并糖尿病是HLP发病的独立危险因素,体检发现重度HTG人群需要警惕HLP的发病风险,通过早期筛查、生活方式干预以及药物治疗等健康管理降低HLP发生率。
Objective To analyze the influencing factors of hyperlipidemic pancreatitis(HLP)in the individuals with severe hypertriglyceridemia(HTG),and provide a reference for the health management of individuals with severe HTG.Methods A retrospective analysis was conducted on the baseline characteristics of 331 patients with severe HTG who underwent health examinations.Based on a history of pancreatitis,the participants were categorized into an HLP group(n=31)and a non-HLP group(n=300).Clinical data between the two groups were compared,and factors influencing the development of HLP were analyzed.Results In the HLP group,the proportion of comorbid diabetes was 45.16%,and the triglyceride(TG)was(26.40±15.58)mmol/L,total cholesterol(TC)was(9.13±3.87)mmol/L,and fasting blood glucose was(8.79±4.30)mmol/L,which were significantly higher than those in the non-HLP group[12.67%,(17.48±7.20)mmol/L,(6.99±2.03)mmol/L,and(7.14±3.37)mmol/L](P<0.05).No significant differences were observed between the two groups in terms of gender,age,body mass index(BMI),history of alcohol consumption,history of smoking,or comorbid hypertension(P>0.05).Multivariate Logistic regression analysis indicated that high TG levels and comorbid diabetes were independent risk factors for the development of HLP(P<0.05).Conclusion High TG levels and comorbid diabetes constitute independent risk factors for the development of HLP.Individuals with severe HTG identified through physical examinations should be vigilant about their risk of developing HLP.Implementing health management strategies—including early screening,lifestyle interventions,and pharmacological treatment—can reduce the incidence of HLP.
作者
孙雪丽
沈志梅
裴昌军
黄玮
田甜
李梅
SUN Xue-li;SHEN Zhi-mei;PEI Chang-jun(Health Management Center,Subei People's Hospital of Jiangsu,Yangzhou 225001,China)
出处
《中国实用医药》
2025年第23期37-40,共4页
China Practical Medicine
基金
江苏省干部保健科研课题(项目编号:BJ20011)。
