摘要
Persistent infection with high-risk human papillomavirus(HR-HPV)is the core pathogenic factor of cervical cancer(CC).Although HPV vaccination is an effective primary prevention method for CC,the global vaccination rate is generally insufficient(target population vaccination rate in China<5%),far from meeting the requirements for herd immunity(80%)and the WHO target(90%).However,only about 10% of HR-HPV infections progress to persistent infections.Therefore,identifying and intervening in the“HR-HPV persistent infection”population can systematically narrow the scope of prevention and control,reduce prevention and control costs,and provide a new path for low-income countries to explore suitable prevention and control models for CC.Based on this understanding,the team has pioneered a systematic method for identifying HR-HPV persistent infections and a tiered intervention system based on drug classification,which has achieved good results in both basic research and clinical observations.This article will summarize the current research status of“HR-HPV persistent infection”in relation to CIN and CC,as well as the team’s relevant concepts and research results,to provide a reference for the identification and intervention of“HR-HPV persistent infection.”
基金
Guizhou Provincial Health Commission(Project No.:gzwkj2023-429)。
