摘要
Bone marrow serves as the life-long home for hemato-poietic stem cells(HSCs)and is the most radio-sensitive organ^([1]).Acute ionizing radiation exceeding 1 Gray(Gy)causes severe damage in bone marrow while no effective drug has been approved in clinical.In a recent work pub-lished in MedComm,Gao and her team reported,for the first time,cannabidiol(CBD)as an outstanding radioprotection agent targeting acute radiation-induced hematopoietic injury^([2]).Within two weeks post radiation,CBD can pro-mote the stemness of hematopoietic stem cells to a regular level.Using single-cell RNA sequencing(scRNA-seq)and functional assay,the authors decoded molecular changes underlying radiation-induced damage and CBD-induced recovery in HSCs.
