摘要
目的探讨脂蛋白a[Lp(a)]对原发性高血压患者炎症状态及心血管的影响。方法回顾性收集2022年1月至2023年11月收治的原发性高血压患者234例的临床资料,根据血清Lp(a)浓度分为正常Lp(a)组(n=185)与高Lp(a)组(n=49),比较两组血清炎症标志物C反应蛋白(CRP)、中性粒细胞与淋巴细胞比值(NLR)、纤维蛋白原的差异;利用Pearson相关分析Lp(a)与炎症标志物的相关性;比较两组患者心脏靶器官损害的发生率。结果与正常Lp(a)组比较,高Lp(a)组高血压患者的CRP浓度、NLR、纤维蛋白原浓度升高(P<0.05,P<0.01);Lp(a)浓度与CRP、NLR、纤维蛋白原具有正相关性(r=0.168、0.165、0.321,P<0.05);高Lp(a)组患者心肌梗死发生率[22.45%(11/49)]较正常Lp(a)组[7.57%(14/185)]高(P<0.01)。结论在原发性高血压患者中,高Lp(a)浓度与炎症反应呈正相关。Lp(a)浓度升高与心肌梗死发生率增加有关,提示Lp(a)可能通过促进炎症影响原发性高血压患者的靶器官损害。
Objective To explore the effect of lipoprotein a[Lp(a)]on the inflammatory state and cardiovascular system of patients with essential hypertension.Methods The clinical data of 234 patients with essential hypertension admitted from January 2022 to November 2023 were retrospectively collected.According to the serum Lp(a)concentration,they were divided into the normal Lp(a)group(n=185)and the high Lp(a)group(n=49).The differences in serum inflammatory markers C reactive protein(CRP),neutrophil-to-lymphocyte ratio(NLR),and fibrinogen between the two groups were compared.Pearson correlation analysis was used to analyze the correlation between Lp(a)and inflammatory markers,and the incidence of cardiac target organ damage between the two groups of patients was compared.Results Compared with the normal Lp(a)group,the CRP concentration,NLR and fibrinogen concentration of hypertensive patients in the high Lp(a)group increased(P<0.05,P<0.01),and the concentration of Lp(a)was positively correlated with CRP,NLR and fibrinogen(r=0.168,0.165,0.321,P<0.05).The incidence of myocardial infarction was higher in the high Lp(a)group[22.45%(11/49)]than in the normal Lp(a)group[7.57%(14/185)](P<0.01).Conclusion In patients with essential hypertension,high Lp(a)concentration is associated with a stronger inflammatory response,and elevated Lp(a)concentration is related to an increased incidence of myocardial infarction,suggesting that Lp(a)may affect target organ damage in patients with essential hypertension by promoting inflammation.
作者
黄煌
王志燕
杨燕
刘奕赓
李松燃
王金环
周新元
宋洋
HUANG Huang;WANG Zhiyan;YANG Yan;LIU Yigeng;LI Songran;WANG Jinhuan;ZHOU Xinyuan;SONG Yang(Department of Cardiology,the 981st Hospital of the Joint Logistics Support Forceof the PLA,Chengde,Hebei 067000,China;Department of Pediatrics,the 981st Hospital of the Joint Logistics Support Forceof the PLA,Chengde,Hebei 067000,China;Department of Immunology,Army Medical University,Chongqing 400038,China)
出处
《免疫学杂志》
2025年第7期483-488,共6页
Immunological Journal
基金
国家自然科学基金(31970838)
河北省卫生健康委员会医学科学研究课题(20232083)。
