摘要
肿瘤已成为严重威胁人类健康和生命的重大疾病,发病率逐年上升,但机制仍不完全明确。中医药是中华民族的瑰宝,也是世界人民的财富,中医药对于肿瘤的治疗发挥着重要作用,越来越受到国内外的广泛关注。前期基于肿瘤的症状和转移特点,通过中医阴阳理论,结合现代医学对肿瘤的研究,提出了“阴虚癌瘤相关”假说,认为机体“阴虚”是恶性肿瘤的主要原因,滋阴以消除阴虚病因治疗癌症,运用滋阴药物达到滋补阴虚进而有效预防恶性肿瘤的发生和发展。常用抗肿瘤滋阴药包括北沙参、百合、麦冬、山麦冬、天冬、石斛、铁皮石斛、玉竹、黄精、枸杞子、桑葚、女贞子、墨旱莲、地黄、知母等。滋阴中药药性多味甘性寒凉质润,具有滋养阴液、生津润燥之功,兼能清热主治阴虚津亏。鉴于滋阴中药以滋补阴虚之法治疗恶性肿瘤的潜在优势和价值,该文对近年以滋阴为主要功效的中药活性成分抗肿瘤作用的相关研究进行总结,然后在诱导肿瘤细胞凋亡、阻滞肿瘤细胞增殖周期、抑制肿瘤的侵袭与转移和血管生产、提高机体免疫及调控功能、增强化疗药作用及逆转肿瘤耐药对抗等方面进一步梳理滋阴中药活性成分抗肿瘤的作用机制,为客观阐述滋阴中药治疗肿瘤的研究进展,为肿瘤防治提供新思路。
Tumor has become a major disease that seriously threatens human health and life.The incidence rate is increasing year by year,yet the underlying mechanisms remain incompletely understood.Traditional Chinese medicine(TCM),a treasure of the Chinese nation and a wealth for people worldwide,plays an important role in the treatment of tumors and has been receiving increasing attention both in China and abroad.In earlier work,based on the symptoms and metastatic characteristics of tumors,and drawing on the TCM theory of Yin and Yang in combination with modern medical research on tumors,the''Yin deficiency-cancer correlation''hypothesis was proposed.This hypothesis holds that''Yin deficiency''of the body is a major cause of malignant tumors,and that nourishing Yin to eliminate the pathogenic factor of Yin deficiency can treat cancer.By using Yin-nourishing drugs to tonify Yin deficiency,the occurrence and development of malignant tumors can be effectively prevented.Common anti-tumor Yinnourishing drugs include Glehniae Radix,Lilii Bulbus,Ophiopogonis Radix,Liriopes Radix,Asparagi Radix,Dendrobii Caulis,Dendrobii Officinalis Caulis,Polygonati Odorati Rhizoma,Polygonati Rhizoma,Lycii Fructus,Mori Fructus,Ligustri Lucidi Fructus,Ecliptae Herba,Rehmanniae Radix,and Anemarrhenae Rhizoma.These drugs are generally sweet in flavor,cold and cool in nature,and moist in texture.They have the functions of nourishing Yin fluids,generating body fluids,and moistening dryness,and can also clear heat,being primarily indicated for Yin deficiency with depletion of body fluids.In view of the potential advantages and value of treating malignant tumors by tonifying Yin deficiency with Chinese medicine,this paper reviews recent studies on the anti-tumor effects of active components of Yin-nourishing drugs.It further summarizes their mechanisms of action in inducing apoptosis of tumor cells,arresting tumor cell proliferation,inhibiting tumor invasion,metastasis,and angiogenesis,enhancing and regulating immune function,augmenting the efficacy of chemotherapeutic drugs,and reversing tumor drug resistance.This study provides an objective overview of research progress on Yin-nourishing drugs in tumor treatment and offers new ideas for cancer therapy.
作者
樊启猛
贺嫣然
明良山
董子舒
刘应蛟
李志新
黄佳
刘红宁
FAN Qimeng;HE Yanran;MING Liangshan;DONG Zishu;LIU Yingjiao;LI Zhixin;HUANG Jia;LIU Hongning*(Institute of Advanced Studies,Research Center for the Differentiated Development of Basic Theory of Traditional Chinese Medicine,Key Laboratory of Chinese Medicine Pathogenesis and Biology,School of Pharmacy,Jiangxi University of Chinese Medicine,Nanchang 330004,China)
出处
《中国实验方剂学杂志》
北大核心
2025年第20期252-265,共14页
Chinese Journal of Experimental Traditional Medical Formulae
基金
中央本级重大增减支项目(2060302)
国家自然科学基金项目(82360782)
江西省教育厅科学技术研究项目(GJJ2400812)
江西省中医药管理局科技计划项目(2021B617)
江西中医药大学科研基金项目(2021BSZR010)
江西中医药大学校级科技创新团队发展计划项目(CXTD22007)。
关键词
肿瘤
滋阴中药
活性成分
多糖
皂苷
生物碱
黄酮
抗肿瘤
作用机制
tumor
Yin-nourishing Chinese medicine
active ingredients
polysaccharides
saponins
alkaloids
flavones
anti-tumor
mechanism
