摘要
膝骨性关节炎(KOA)是一种以关节软骨退变和滑膜炎症为特征的慢性退行性骨关节病。随着对肠道菌群的深入研究,众多学者提出KOA的发病机制可能与肠道通透性、肠道微生物和肠道免疫等肠道微环境密切相关。针灸可以调节肠道微生物群,改善肠道微生态,从而治疗膝骨性关节炎。本研究以“肠-关节”轴为理论基础,阐述肠道内环境与KOA的关系,揭示针灸通过调节肠道微环境治疗膝骨性关节炎的相关机制,促进机制研究成果更好地向临床应用转化,以期为临床治疗骨关节疾病提供新策略。
Knee osteoarthritis(KOA)is a chronic degenerative joint disease characterized by articular cartilage degeneration and synovial inflammation.With in-depth research on gut microbiota,numerous scholars have proposed that the pathogenesis of KOA may be closely related to the gut microenvironment,including gut permeability,gut microbiota,and gut immunity.Acupuncture and moxibustion can regulate gut microbiota and improve gut microecology,thereby treating knee osteoarthritis.Based on the theoretical framework of the"gut-joint"axis,this study elucidates the relationship between gut internal environment and KOA,reveals the relevant mechanisms by which acupuncture and moxibustion treat knee osteoarthritis by regulating the gut microenvironment,and promotes the better translation of mechanism research results into clinical application,with the aim of providing new strategies for the clinical treatment of osteoarthritis.
作者
闫蓉蓉
王树东
胡哲
YAN Rongrong;WANG Shudong;HU Zhe(Liaoning University of Traditional Chinese Medicine,Shenyang,Liaoning 110847)
出处
《中医康复》
2025年第11期11-15,共5页
Traditional Chinese Medicine Rehabilitation
基金
辽宁省科技厅面上项目(2023-MS-229)
辽宁省教育厅课题(LJKZ0878)。
关键词
膝骨性关节炎
“肠-关节”轴
针灸
肠道微生物群
knee osteoarthritis
"gut-joint"axis
acupuncture and moxibustion
gut microbiota
