摘要
目的:探讨在宫颈癌根治术患者麻醉中应用腹横肌平面阻滞复合静吸全麻的效果。方法:选取2019年6月—2024年12月福清市妇幼保健院收治的82例宫颈癌根治术患者为研究对象,通过随机数表法均分为常规组(41例)和研究组(41例)。常规组应用静吸全麻,研究组应用腹横肌平面阻滞复合静吸全麻。比较两组术后镇痛效果,术中不同时刻血流动力学,手术前后氧化应激水平及不良反应发生情况。结果:研究组数字评价量表(NRS)在术后6 h、12 h、24 h均低于常规组,差异有统计学意义(P<0.05);两组Ramsay镇静评分比较,差异无统计学意义(P>0.05)。麻醉前,两组心率、平均动脉压比较,差异无统计学意义(P>0.05);麻醉后5 min,研究组比常规组更高,且拔管时研究组比常规组更低,差异有统计学意义(P<0.05);术前,两组超氧化物歧化酶(SOD)、丙二醛(MDA)、总抗氧化能力(T-AOC)水平相近,差异无统计学意义(P>0.05);术后SOD、T-AOC均降低明显,但研究组较常规组降低幅度小,MDA均提高明显,但研究组较常规组提高幅度小,差异有统计学意义(P<0.05);研究组和常规组不良反应发生率相近,差异无统计学意义(P>0.05)。结论:在宫颈癌根治术患者麻醉中应用腹横肌平面阻滞复合静吸全麻,能够有效降低术后疼痛和氧化应激反应,稳定术中血流动力学,且安全性较高。
Objective:To investigate the effect of transverse abdominal muscle plane block combined with general anesthesia during radical cervical cancer operation.Method:From June 2019 to December 2024,82 consecutive patients scheduled for radical hysterectomy in Fuqing Maternal and Child Health Hospital were randomly assigned with random number method to a control group(n=41)receiving balanced intravenous-inhalational general anesthesia alone and a study group(n=41)receiving TAP block in addition to the same general anesthetic regimen.Postoperative analgesia,intraoperative hemodynamics at specified time points,perioperative oxidative stress markers,and adverse events were compared.Result:Numeric Rating Scale(NRS)pain scores at 6,12,and 24 h postoperatively were significantly lower in the study group than in the control group(P<0.05).Ramsay sedation scores did not differ between groups(P>0.05).Baseline heart rate(HR)and mean arterial pressure(MAP)were comparable(P>0.05).Five minutes after induction,HR and MAP were higher in the study group than in the control group,while at extubation they were lower in the study group(P<0.05).Before operation,the levels of superoxide dismutase(SOD),malondialdehyde(MDA)and total antioxidant capacity(T-AOC)were similar between the two groups,but there was no statistically significant difference(P>0.05).SOD and T-AOC were significantly reduced after operation,but the reduction of the study group was smaller than that of the conventional group.MDA was significantly increased in both groups,but the increase in the study group was smaller than that in the conventional group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions was similar between the study group and the conventional group,and the difference was not statistically significant(P>0.05).Conclusion:The application of transversal muscle plane block combined with general anesthesia during radical cervical cancer operation can effectively reduce postoperative pain and oxidative stress reaction,stabilize intraoperative hemodynamics,and have high safety.
作者
吴迁海
WU Qianhai(Fuqing Maternal and Child Health Hospital,Fuqing 350300,China)
出处
《中外医学研究》
2025年第25期9-12,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
腹横肌平面阻滞
静吸全麻
宫颈癌根治术
血流动力学
Transverse abdominis plane block
Intravenous general anesthesia
Cervical cancer radical surgery
Hemodynamics
