摘要
目的:探讨血府逐瘀汤联合单唾液酸四己糖神经节苷脂钠注射液治疗脑外伤后综合征(PTBS)对患者主观症状与颅内各动脉平均血流速度的影响。方法:选取2021年2月-2024年2月南昌市洪都中医院收治的68例PTBS患者,采用随机数字表法将其分为对照组(34例)和联合组(34例)。对照组给予单唾液酸四己糖神经节苷脂钠注射液治疗,联合组在此基础上给予血府逐瘀汤治疗,两组均连续治疗4周。比较两组疗效、主观症状评分、中医证候积分、颅内各动脉平均血流速度[大脑前动脉(ACA)、大脑后动脉(PCA)、基底动脉(BA)]、NIHSS评分、世界卫生组织生存质量测定量表简表(WHOQOL-BREF)各维度评分及不良反应发生率。结果:治疗后,联合组的总有效率高于对照组(P<0.05);相较于治疗前,治疗后两组中医证候积分、主观症状评分、NIHSS评分均明显降低,且联合组低于对照组(P<0.05);两组治疗后ACA、PCA、BA的平均血流速度明显更快,WHOQOL-BREF各维度评分均明显升高,且联合组优于对照组(P<0.05);治疗过程中两组患者的不良反应发生率比较差异无统计学意义(P>0.05)。结论:PTBS患者经血府逐瘀汤联合单唾液酸四己糖神经节苷脂钠注射液治疗的效果显著,能够有效缓解患者的临床症状,提升颅内各动脉平均血流速度,改善生活质量,且治疗安全性较好。
Objective:To investigate the effect of Xuefu Zhuyu Decoction combined with Monosialotetrahexosyl-ganglioside Sodium Injection on subjective symptoms and average blood flow velocity of intracranial arteries in patients with post-traumatic brain syndrome(PTBS).Method:A total of 68 patients with PTBS admitted to Nanchang Hongdu Hospital of Traditional Chinese Medicine from February 2021 to February 2024 were selected and divided into control group(34 cases)and combination group(34 cases)by random number table method.The control group was treated with Monosialotetrahexosylganglioside Sodium Injection,while the combination group was treated with Xuefu Zhuyu Decoction on this basis.Both groups were treated continuously for 4 weeks.The efficacy,subjective symptom scores,traditional Chinese medicine syndrome scores,mean blood flow velocity of intracranial arteries[anterior cerebral artery(ACA),posterior cerebral artery(PCA),basilar artery(BA)],NIHSS scores,World Health Organization quality of life-brief version(WHOQOL-BREF)scores in various dimensions,and incidence of adverse reactions between two groups were compared.Result:After treatment,the total effective rate of the combination group was higher than that of the control group(P<0.05);compared with those before treatment,the scores of traditional Chinese medicine syndrome,subjective symptom,and NIHSS in both groups decreased significantly after treatment,and those of the combination group were lower than those of the control group(P<0.05);after treatment,the mean blood flow velocity of ACA,PCA,and BA of the two groups were significantly faster,the scores of WHOQOL-BREF in all dimensions were significantly increased in both groups,and those of the combination group were better than those of the control group(P<0.05);there was no statistically significant difference in the incidence of adverse reactions between the two groups of patients during the treatment process(P>0.05).Conclusion:The combination of Xuefu Zhuyu Decoction and Monosialotetrahexosylganglioside Sodium Injection has a significant therapeutic effect on PTBS patients,which can effectively alleviate their clinical symptoms,improve the mean blood flow velocity of intracranial arteries,enhance their quality of life,and have good treatment safety.
作者
涂其武
万坤华
TU Qiwu;WAN Kunhua(Second Department of Surgery,Nanchang Hongdu Hospital of Traditional Chinese Medicine,Nanchang 330006,China;不详)
出处
《中国医学创新》
2025年第26期18-22,共5页
Medical Innovation of China
关键词
血府逐瘀汤
单唾液酸四己糖神经节苷脂钠注射液
脑外伤后综合征
主观症状
颅内各动脉平均血流速度
Xuefu Zhuyu Decoction
Monosialotetrahexosylganglioside Sodium Injection
Post-traumatic brain syndrome
Subjective symptoms
Mean blood flow velocity of intracranial arteries
