摘要
活血化瘀法治疗肿瘤在中医肿瘤治疗理论中占有重要地位,但活血化瘀药对肿瘤转移的影响在临床上存在一定的争议,使得活血化瘀药对肿瘤转移的影响研究备受关注。文章结合中医对肿瘤病因病机的认识,从活血化瘀药影响肿瘤血管生成、诱导肿瘤血管正常化、干扰肿瘤细胞Warburg效应等方面详细阐述活血化瘀药及其效应成分影响肿瘤转移的分子机制,为活血化瘀法抗肿瘤治疗理论提供依据。
The method of promoting blood circulation and removing blood stasis holds a significant position in the theoretical framework of traditional Chinese medicine(TCM)for cancer treatment.However,the impact of blood-activating and stasis-eliminating herbs on tumor metastasis remains a subject of clinical uncertainty,which has drawn considerable attention to research on their effects.Based on TCM’s understanding of the etiology and pathogenesis of tumors,this article elaborates on the molecular mechanisms through which blood-activating and stasis-eliminating Chinese herbs and their active components influence tumor metastasis.This includes their roles in affecting tumor angiogenesis,inducing normalization of tumor blood vessels,and interfering with the Warburg effect in tumor cells.The findings provide a scientific basis for the anti-tumor theory of the blood-activating and stasis-eliminating approach.
作者
朱紫妍
朱芸萱
陈琼
邹珏瑶
王爱云
赵杨
陆茵
陈文星
ZHU Ziyan;ZHU Yunxuan;CHEN Qiong;ZOU Jueyao;WANG Aiyun;ZHAO Yang;LU Yin;CHEN Wenxing(School of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210023,China;Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica,Nanjing 210023,China;Jiangsu Collaborative Innovation Center for TCM Prevention and Treatment of Tumors,Nanjing 210023,China)
出处
《南京中医药大学学报》
北大核心
2025年第9期1251-1257,共7页
Journal of Nanjing University of Traditional Chinese Medicine
基金
国家自然科学基金面上项目(82274150)
江苏省研究生科研创新基金(KYCX23_2051)。
关键词
活血化瘀药
抗肿瘤
肿瘤转移
血管生成
血管正常化
Warburg效应
blood-activating and stasis-eliminating drugs
anti-tumor
tumor metastasis
angiogenesis
vascular normalization
Warburg effect
