摘要
溃疡性结肠炎(Ulcerative colitis,UC)是一种慢性肠道性炎症性疾病,现有的治疗方法如免疫抑制剂和生物制剂可部分缓解临床症状,但尚未针对病因学机制进行干预,且存在药物耐药性和不良反应问题。随着研究的深入,肠道菌群失衡和免疫系统异常被认为在UC的发生和发展中起着关键作用。中医理论中,脾胃是人体气血生化的基础,脾为“后天之本”,主运化水湿,维持身体内外的平衡。脾为之卫理论认为,脾脏通该文旨在探讨基于脾为之卫理论,通过肠道菌群调节治疗UC的可能性。着重探讨脾为之卫理论在调节肠道菌群,治疗UC方面的重要作用,为UC的治疗提供了新的理论框架和治疗思路。
Ulcerative colitis(UC)is a chronic inflammatory disease of the intestine.Existing treatment methods such as immunosuppressants and biologics can alleviate symptoms to some extent,but they have not fundamentally solved the cause,and there are issues of drug resistance and side effects.With the deepening of research,the imbalance of gut microbiota and immune system abnormalities are believed to play a key role in the occurrence and development of UC.In traditional Chinese medicine theory,the spleen and stomach are the basis of the bodys qi,blood,and biochemistry.The spleen is the"foundation of nurture"and is responsible for regulating the flow of water and dampness,maintaining balance between the inside and outside of the body.The theory of spleen as the defense holds that the spleen plays an important role in defending the body from invasion by external pathogens through its transport and immune regulation functions.This article aims to explore the possibility of treating UC through the regulation of gut microbiota based on the theory of spleen as the defender.Emphasis is placed on exploring the important role of the spleen as the defender theory in regulating gut microbiota and treating UC,providing a new theoretical framework and treatment approach for the treatment of UC.
作者
张涛
于永铎
ZHANG Tao;YU Yongduo(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China)
出处
《实用中医内科杂志》
2025年第8期126-129,共4页
Journal of Practical Traditional Chinese Internal Medicine
基金
辽宁省“兴辽英才计划”项目(XLYC2002002)
辽宁省重点研发计划项目(2020JH2/10300062)
辽宁省科技厅高校基本科研项目(2024-JYTCB-071)。
关键词
溃疡性结肠炎
肠道菌群
脾为之卫
Ulcerative colitis
Intestinal flora
Spleen as the guardian
