摘要
脓毒症(Sepsis)是指宿主对感染的反应失调而导致危及生命的器官功能障碍,病死率居高。脓毒症导致多脏器功能障碍,其中胃肠道是最容易受损的器官,且损伤机制复杂,涉及炎性反应、肠道屏障损害、肠道菌群失调、免疫失调等。目前临床上对脓毒症诱导的胃肠道损伤的治疗限于对症支持治疗,但随着对其机制的深入研究,一些新的治疗方法如免疫治疗、中药治疗等被用于脓毒症的治疗当中。本文对胃肠功能损伤的发病机制和治疗进展进行了综述,希望为脓毒症胃肠功能损伤的治疗提供帮助。
Sepsis refers to the dysregulation of the hosts response to infection,resulting in life-threatening organ dysfunction,with a high fatality rate.Sepsis leads to multi-organ dysfunction.Among them,the gastrointestinal tract is the most vulnerable organ,and the damage mechanism is complex,involving inflammatory response,intestinal barrier damage,intestinal flora imbalance,Immune disorders,etc.At present,the treatment of sepsis-induced gastrointestinal injury is limited to symptomatic and supportive treatment in clinical practice.However,with the in-depth study of its mechanism,some new treatments such as immunotherapy and traditional Chinese medicine treatment have been used in the treatment of sepsis.This article reviews the pathogenesis and treatment of gastrointestinal dysfunction,hoping to provide help for the treatment of gastrointestinal dysfunction in sepsis.
作者
黄静
谢胜
HUANG Jing;XIE Sheng(Graduate School of Guangxi University of Traditional Chinese Medicine,Nanning 530200,Guangxi,China;The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine,Nanning 530023,Guangxi,China)
出处
《实用中医内科杂志》
2025年第8期88-92,共5页
Journal of Practical Traditional Chinese Internal Medicine
基金
广西岐黄学者培养项目(2022015-003-01)。
关键词
脓毒症
胃肠功能损伤
炎性反应
肠道菌群
sepsis
gastrointestinal injury
inflammatory response
intestinal microbiota
