摘要
目的 研究标记后延迟时间(PLD)为1.5 s及2.5 s时,动脉自旋标记(ASL)灌注成像在缺血性脑白质高信号中的应用价值。方法 回顾性分析焦作市人民医院2020年1月—2023年12月拥有完整的MRI平扫、ASL(PLD=1.5 s)、ASL(PLD=2.5 s)影像资料,临床有脑缺血症状,且T2FLAIR序列上显示为脑白质点状高信号的患者130例,病灶共308个;选取患者病灶对侧正常脑组织作为对照组。在工作站上分别测量病灶区及对侧正常区域的脑血流量最小值(CBFmin),并比较组间差异及各检查方法的敏感性。结果 PLD=1.5 s时,病灶区CBFmin值[20(14~27)mL/(100 g·min)]和对侧正常区CBFmin值[23(16~32)mL/(100 g·min)]比较,差异有统计学意义(Z=-8.191,P<0.001);PLD=2.5 s时,病灶区CBFmin值[26(21~32)mL/(100 g·min)]和对侧正常区CBFmin值[31(25~38)mL/(100 g·min)]比较,差异有统计学意义(Z=-11.722,P<0.001)。PLD=1.5 s、PLD=2.5 s、PLD=1.5 s联合2.5 s对低灌注病灶的检出率分别为69.8%、83.4%、93.8%,差异有统计学意义(χ^(2)=61.559,P<0.001)。结论 双PLD扫描有助于提高低灌注病灶的检出率,且PLD=2.5 s时低灌注病灶的检出率高于PLD=1.5 s。
Objective To investigate the application of arterial spin labeling(ASL)perfusion imaging in ischemic white matter hyperintensity at double post-labeling delay(PLD)time of 1.5s and 2.5s.Methods A retrospective analysis was conducted on 130 patients in Jiaozuo People’s Hospital from January 2020 to December 2023.These patients had complete imaging data of MRI non-contrast scan,ASL(PLD=1.5 s)and ASL(PLD=2.5 s),presented with clinical symptoms of cerebral ischemia,as well as showed punctate hyperintense signals in the cerebral matter on the T2FLAIR sequence.A total of 308 lesions in these patients were identified.The normal brain tissue on the contralateral side of the lesions was selected as the control group.The minimum cerebral blood flow(CBFmin)in the lesion area and the contralateral normal area was respectively measured at the workstation,and the differences between the groups and the sensitivity of each examination method were compared.Results There was a significant difference between the CBFmin value in the lesion area and the CBFmin value in the contralateral normal area,when the PLD was 1.5 s(Z=-8.191,P<0.001).There was a significant difference in the CBFmin value between the lesion area and the contralateral normal area when the PLD was 2.5 s(Z=-11.722,P<0.001).The detection rates of hypoperfusion lesions were 69.8%,83.4%,93.8%,respectively,showing significant differences,when PLD=1.5 s,PLD=2.5 s,and PLD=1.5 s combined with 2.5 s(χ^(2)=61.559,P<0.001).Conclusions Double PLD scans are helpful to enhance the detection rate of hypoperfusion lesions.The detection rate of PLD=2.5 s was higher than that of PLD=1.5 s.
作者
牛海彬
吴佳斌
杜红
张伟
NIU Haibin;WU Jiabin;DU Hong;ZHANG Wei(Magnetic Resonance Imaging Room,Jiaozuo People’s Hospital,Jiaozuo 454001,Henan,China)
出处
《中国校医》
2025年第6期466-468,478,共4页
Chinese Journal of School Doctor
