摘要
Rh血型系统是具有临床意义的血型系统之一,Rh血型系统不相容性输血可引起同种免疫反应,导致患者发生溶血性输血反应、胎儿及新生儿溶血病(HDFN)等严重不良反应,威胁患者生命健康。近年有关RHD以及RHCE基因变异的前沿研究取得显著进展,不仅为输血方案的革新注入动力,也为血液资源管理提供了新思路。本文通过介绍Rh血型系统抗原分布、分子基础研究、临床应用及技术创新方面的最新进展,旨在为优化输血策略,提升输血安全及疗效提供理论参考和实验指导。
The Rh blood group system is one of the most clinically significant blood group systems.Incompatibility in this system can lead to alloimmunization,resulting in severe adverse reactions such as hemolytic transfusion reactions in patients and hemolytic disease of the fetus and newborn(HDFN),which threaten patient lives.Recent cutting-edge research on RHD and RHCE variants has yielded significant progress,providing not only an impetus for innovating transfusion protocols but also novel strategies for the management of blood resources.This article reviews the latest advances in the distribution of Rh antigens,their molecular basis,clinical applications,and associated technological innovations,with the aim of optimizing transfusion strategies to enhance safety and efficacy.
作者
李景琦
祁术元
耿凌云
LI Jingqi;QI Shuyuan;GENG Lingyun(Capital Center for Children's Health,Capital Medical University,Beijing 100020)
出处
《临床输血与检验》
2025年第5期712-717,共6页
Journal of Clinical Transfusion and Laboratory Medicine
关键词
RH血型系统
基础研究
同种抗体
变异体
精准输血
Rh blood group system
Basic research
Alloantibody
Variant
Precision transfusion
