摘要
原发性醛固酮增多症(PHA)——继发性高血压最常见的病因,可导致心脑血管及肾脏损害事件发生,对其早期诊断及精准分型之于治疗方案的选择至关重要。常用的PHA诊断方式包括卧立位试验筛查、卡托普利试验定性和肾上腺静脉采血定位分型诊断,但随着影像学、分子生物学和形态学技术的发展,核医学正电子发射断层显像-计算机断层扫描(PET-CT)、基因检测和病理诊断等新兴诊疗技术也在PHA的诊断和精准分型方面发挥着重要作用。此外,肾上腺动脉栓塞及肾上腺射频消融等新技术也越来越多地被用于PHA的治疗,且具有手术时间短、费用少、术后并发症少和恢复快等优点。本文就PHA的筛查、诊断和治疗的进展做一综述,以期为临床实践提供参考。
Primary hyperaldosteronism(PHA),the most common cause of secondary hypertension,can lead to cardiovascular and renal damage events.Early diagnosis and accurate typing of PHA is crucial to the choice of treatment options,and its diagnostic modalities usually include prone test screening,captopril test characterization and adrenal vein blood sampling for localization and typing diagnosis.However,with the development of imaging,molecular biology and morphology technologies,the use of nuclear medicine PET-CT,genetic testing and pathological diagnostic methods can also be used to accurately typify PHA.New technologies such as adrenal artery embolization and adrenal radiofrequency ablation are also increasingly being used in the treatment of PHA,which have the advantages of shorter and less costly surgery,fewer postoperative complications,and quicker recovery.This article provides a review of the developments in the screening,diagnosis and treatment of PHA with a view to informing clinical practice.
作者
廖华生
吴逸钊
邓偲
敖子建
张利朝
LIAO Huasheng;WU Yizhao;DENG Cai;AO Zijian;ZHANG Lichao(Department of Urology,The 12th People's Hospital of Guangzhou,Guangzhou 510799;Department of Urology,The Second Affiliated Hospital of Guangzhou Medical University,Guangzhou 510120,China)
出处
《现代泌尿外科杂志》
2025年第9期797-802,共6页
Journal of Modern Urology
基金
省医学科学技术研究基金项目(No.B2024016)。
关键词
原发性醛固酮增多症
肾上腺静脉采血
射频消融
动脉栓塞
primary hyperaldosteronism
adrenal vein sampling
radiofrequency ablation
arterial embolization
