摘要
在原发性醛固酮增多症(primary aldosteronism,PA)的传统药物治疗中以醛固酮拮抗剂(螺内酯)在临床上使用最为广泛,但大剂量使用后其不良反应明显,因此PA治疗的药物选择和使用方法是临床上十分重要的问题。近年来,随着选择性醛固酮受体阻滞剂、非醛固酮拮抗剂类利尿药、钙离子拮抗剂、血管紧张素转换酶抑制剂、血管紧张素受体阻滞剂等药物在PA治疗中的应用日渐广泛,临床医生对PA的药物治疗有了新的认识。本文就近年来关于PA的药物治疗的进展情况做一介绍。
Spironolactone has been widely used in clini- cal treatment of PA, but its adverse effects are prominent when at large dose. So it is very important for clinicians to choose proper medications and doses for PA. With widespread use of selective aldosterone-receptor antagonists, non-aldosterone an- tagonists diuretic, calcium antagonists, angiotensin-converting enzyme inhibitors and angiotensin-reeeptor blocker in treatment of PA,elilicians now have more choice. This review introduces the progress in medications of PA in recent years.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2010年第1期17-19,共3页
Chinese Journal of Practical Internal Medicine
