摘要
目的分析女性首发精神分裂症患者认知功能与外周血炎症指标及激素水平的相关性。方法选取苏州市广济医院于2021年6月至2024年6月收治的108例女性首发精神分裂症患者,纳入患者组,并选取同期50名健康体检女性,纳入对照组。使用蒙特利尔认知量表(MoCA)评估患者认知功能,并检测其外周血炎症指标和激素水平,并使用Pearson相关性分析相关性。结果患者组的MoCA评分较对照组更低,白介素-2(IL-2)、白介素-4(IL-4)、白介素-6(IL-6),以及孕激素(P)、睾酮(T)和催乳素(PRL)水平均较对照组更高,黄体生成素(LH)、促卵泡激素(FSH)、雌二醇(E2)水平均较对照组更低(P均<0.05)。Pearson相关性分析示,患者MoCA评分与外周血IL-2、IL-4、IL-6、PRL、P、T水平均呈负相关,与LH、FSH、E2水平均呈正相关(P均<0.05)。结论女性首发精神分裂症患者的认知功能显著受损,并伴有炎症因子和激素水平异常,且患者的认知功能变化与炎症指标、激素水平变化存在明显关联。
Objective To analyze the correlation of cognitive function with peripheral blood inflammatory indicators and hormone levels in female patients with first-episode schizophrenia.Methods A total of 108 female patients with first-episode schizophrenia admitted to Suzhou Guangji Hospital from June 2021 to June 2024 were selected as the patient group,and 50 healthy women who underwent physical examinations during the same period were selected as the control group.The Montreal Cognitive Assessment(MoCA)was used to evaluate their cognitive function,and their peripheral blood inflammatory indicators and hormone levels were detected.Pearson Correlation Analysis was used for the purpose of data analysis.Results Compared with the control group,the patient group showed a lower MoCA score,higher levels of interleukin-2(IL-2),interleukin-4(IL-4),interleukin-6(IL-6),progestogen(P),testosterone(T),and prolactin(PRL),and lower levels of luteinizing hormone(LH),follicle-stimulating hormone(FSH),and estradiol(E2)(P<0.05).Pearson Correlation Analysis showed that the MoCA score of patients was negatively correlated with the levels of IL-2,IL-4,IL-6,PRL,P,and T of peripheral blood,and was positively correlated with the levels of LH,FSH,and E2(P<0.05).Conclusion Female patients with first-episode schizophrenia have significantly impaired cognitive function,accompanied by abnormal levels of inflammatory factors and hormone levels.There is a significant correlation between changes in cognitive function and changes in inflammatory indicators and hormone levels.
作者
张琳
李定萍
ZHANG Lin;LI Dingping(Suzhou Guangji Hospital,Suzhou,Jiangsu,215000,China)
出处
《中西医结合护理(中英文)》
2025年第6期153-156,共4页
Journal of Clinical Nursing in Practice
关键词
女性首发精神分裂症
认知功能
炎症指标
激素水平
相关性分析
first-episode schizophrenia in women
cognitive function
inflammatory indicator
hormone level
correlation analysis
