摘要
种植体骨结合是指承载负荷的种植体与周围有序的骨组织之间形成的结构性、功能性直接连接,该过程复杂且涉及多种细胞类型的相互作用。成骨细胞在种植体表面黏附、增殖和分化,通过一系列生物学过程促进种植体与周围骨组织的结合,对骨结合的实现至关重要。良好的骨结合可增强种植体稳定性、降低感染风险,进而提高修复成功率,改善患者生活质量。然而,研究表明糖尿病会干扰骨结合过程,降低种植体成功率,为增强糖尿病患者的种植体骨结合,研究人员开发了多种新材料和新工艺,如持续抗菌材料、生物因子缓释材料及表面改性技术等。其中,种植体表面处理因能提高骨结合性能、增强生物相容性及抗菌性而备受关注。本文综述了机械处理、涂层修饰、生物材料支架等种植体表面处理方式的作用原理与应用效果。
Osseointegration of implants is defined as the direct structural and functional connection between a loaded implant and the surrounding ordered bone tissue.This process is complex,involving the interactions among multiple cell types.Osteoblasts adhere to,proliferate on,and differentiate at the implant surface,and through a sequence of biological processes,they facilitate the integration of the implant with the adjacent bone tissue—an event pivotal to osseointegration.Robust osseointegration enhances implant stability,reduces the risk of infection,and thereby increases the success rate of restoration and improving patients’quality of life.However,studies indicate that diabetes can impede the osseointegration process and lower the implant success rate.To enhance osseointegration in diabetic patients,researchers have developed a variety of novel materials and techniques,including continuous antibacterial materials,biological factor sustained-release materials and surface modification techniques.Among these,implant surface treatment has attracted significant attention due to its ability to improve osseointegration performance while enhancing biocompatibility and antibacterial properties.This article reviews the principles and efficacy of various implant surface treatment methods,such as mechanical treatments,coating technologies,and biomaterial scaffolds.
作者
王英杰
王梦雪
曹语
许姿曼
徐雨欧
刘乐华
Wang Yingjie;Wang Mengxue;Cao Yu;Xu Ziman;Xu Yuou;Liu Lehua(Huzhou University,School of Medicine&School of Nursing,Huzhou 313000,Zhejiang,China)
出处
《中国口腔种植学杂志》
2025年第4期405-411,共7页
Chinese Journal of Oral Implantology
基金
全国大学生创新创业培训计划(202410347042)
浙江省大学生科技创新活动计划新苗人才计划项目(2024R430A018)。
关键词
牙种植体
骨结合
成骨细胞
涂层材料
Dental implants
Osseointegration
Osteoblast
Coated materials
