摘要
双膦酸盐(BP)是治疗骨质疏松及骨相关肿瘤的常用药物之一,对骨代谢有较大影响。在摄入BP的患者群体中进行种植义齿修复时,BP对种植体骨结合的形成及长期维持的潜在作用不容忽视。此外,种植体的植入是否影响BP介导的药物相关性颌骨坏死的发生也备受关注。本文基于近年动物及临床研究证据,探讨BP对种植体骨结合形成及长期稳定的潜在作用,并分析种植治疗对BP相关性颌骨坏死的影响,最后为摄入BP患者的种植治疗提出临床建议,以期为相关研究及临床治疗提供理论参考。
Bisphosphonates(BP),a class of commonly used medications for treating osteoporosis and bone malignancies,significantly affect bone metabolism.When dental implants are placed in patients receiving BP,the potential impacts of BP on the formation and long-term maintenance of implant osseointegration cannot be ignored.In addition,the influence of dental implants on the occurrence of BP-related osteonecrosis of the jaw is garnering attention.This article explores the influences of BP on the stability of dental implants based on a review of previous animal and clinical studies,discusses the impact of dental implants on the occurrence of BP-related osteonecrosis of the jaw,and proposes suggestions for the dental implant treatment of patients taking BP in clinical practice.This review is expected to provide a theoretical basis for the related research and clinical treatment.
作者
贾凌璐
公子恺
赵文锡
文勇
JIA Linglu;GONG Zikai;ZHAO Wenxi;WEN Yong(Department of Prosthodontics,School and Hospital of Stomatology,Cheeloo College of Medicine,Shandong University,Jinan 250012,China;Shandong Key Laboratory of Oral Tissue Regeneration,Jinan 250012,China;Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration,Jinan 250012,China;Shandong Provincial Clinical Research Center for Oral Diseases,Jinan 250012,China;Department of Implantology,School and Hospital of Stomatology,Cheeloo College of Medicine,Shandong University,Jinan 250012,China)
出处
《中国医学科学院学报》
北大核心
2025年第4期628-633,共6页
Acta Academiae Medicinae Sinicae
基金
山东大学口腔医院科研基金(2024YJLC01、2024YJLC04)
山东省自然科学基金(ZR2022QH099、ZR2024MH274)。
关键词
双膦酸盐
种植体
骨结合
药物相关性颌骨坏死
bisphosphonates
implants
osseointegration
medication-related osteonecrosis of the jaw
