摘要
中晚期肝细胞癌患者初诊时多数合并有门静脉癌栓,具有并发症发生率高、治疗不耐受等特点,预后极差。肝细胞癌合并门静脉癌栓是治疗肝细胞癌的一大难题。随着治疗理念、局部治疗技术、靶向及免疫治疗药物的发展,多种治疗方式联合的转化治疗成为一种新的研究趋势。然而,目前尚无被广泛接受的转化治疗方案。本文就肝细胞癌合并门静脉癌栓的诊疗现状及多种治疗方式联合的转化治疗方案进行归纳、总结,以期为肝细胞癌临床诊疗提供依据。
Most patients with advanced hepatocellular carcinoma(HCC)had portal vein tumor thrombus(PVTT)at initial diagnosis,which is characterized by high complication rate,treatment intole-rance and poor prognosis.HCC combined with PVTT is a major challenge in the treatment of liver cancer.With progress in therapeutic concept,locoregional therapy,targeted and immunotherapy,the combination of multiple modalities for translational therapy has become a new paradigm.However,there is no widely accepted protocol for translational therapy.This article summarizes the current diagnosis and treatment of HCC combined with PVTT,and the research protocols of combined translational therapy with various modalities,aiming to provide a basis for the future clinical reference.
作者
尚栋良
薛飞
Shang Dongliang;Xue Fei(Department of Hepatobiliary and Pancreatic Surgery,Zhengzhou University People's Hospital(Henan Provincial People's Hospital),Zhengzhou 450003,China)
出处
《中华肝胆外科杂志》
北大核心
2025年第8期628-632,共5页
Chinese Journal of Hepatobiliary Surgery
基金
河南省科技攻关项目(222102310152)
河南省留学人员科研择优资助项目[豫人社办函(2023)8号]。
关键词
癌
肝细胞
门静脉
转化治疗
进展
Carcinoma,hepatocellular
Portal vein
Conversion therapy
Advances
