摘要
目的探讨定坤丹联合电刺激治疗对子宫内膜薄型不孕症患者子宫内膜形态、排卵功能影响。方法收集2020年10月—2022年10月医院收治的106例子宫内膜薄型不孕症患者,随机分为研究组和对照组各53例。对照组采用电刺激治疗,研究组在对照组的基础上联合定坤丹进行治疗。对比患者临床疗效、子宫内膜形态(A型、B型、C型)、子宫内膜厚度及卵泡发育情况、子宫动脉搏动指数(pulse index,PI)、子宫动脉阻力指数(resistance index,RI)、黄体生成素(luteinizing hormone,LH)、雌二醇(estradiol,E_(2))、促卵泡激素(follicle-stimulating hormone,FSH)、临床妊娠、绒毛膜促性腺激素(human choionic gonadotophin,HCG)阳性、活产率以及早期流产率。结果治疗后,研究组的总有效率92.45%高于对照组77.36%(P<0.05)。治疗后,两组子宫内膜形态A型占比均上升,B型、C型占比均下降,且研究组改善程度优于对照组(P<0.05)。治疗后,两组子宫内膜厚度及成熟卵泡直径均增加,卵泡排出时间均减少,且研究组改善程度优于对照组(P<0.05)。治疗后,两组PI、RI水平均降低,且研究组较对照组更低(P<0.05)。治疗后,两组E_(2)水平均提升,LH、FSH水平均下降,且研究组改善程度优于对照组(P<0.05)。治疗后,研究组临床妊娠率、HCG阳性率高于对照组(P<0.05),早期流产率、活产率差异无统计学意义(P>0.05)。结论定坤丹联合电刺激治疗对子宫内膜薄型不孕症患者疗效明显,能有效改善子宫内膜形态、促进排卵功能,从而提高妊娠率。
Objective To investigate the effect of Dingkun Pill(定坤丹)combined with electrical stimulation therapy on endometrial morphology and ovulatory function in infertility women with thin endometrium.Methods One hundred and six infertility women with thin endometrium admitted to the hospital from October 2020 to October 2022 were collected and randomly grouped,each with 53 cases.The control group was treated with electrical stimulation therapy.Based on this,the study group added Dingkun Pill.Then the clinical outcome,endometrial morphology(type A,B,C),endometrial thickness,follicular development,pulsatility index(PI),resistance index(RI),luteinizing hormone(LH),oestradiol(E_(2)),follicle-stimulating hormone(FSH),clinical pregnancy rate,human chorionic gonadotropin(HCG)positive rate,live birth rate and early miscarriage rate were compared between groups.Results The overall efficacy rate was 92.45%in the study group,which was higher than 77.36%in the control group(P<0.05).An increase in percentage of endometrial morphology type A,and a decrease in percentage of type B and C were observed in all patients,and the improvements were more notable in the study group than those in the control group(P<0.05).The endometrial thickness and diameter of dominant follicles showed an increase in all patients,and the increase was more remarkable in the study group than that in the control group(P<0.05).The values of PI and RI decreased in all patients after treatment,and the two indices were lower in the study group than those in the control group(P<0.05).An increase in E_(2),and a decrease in LH and FSH were detected in all patients after treatment,and both changes were more significant in the study group than those in the control group(P<0.05).The study group reported a higher clinical pregnancy rate and HCG positive rate than the control group(P<0.05),and no statistical difference was found in early miscarriage rate and live birth rate between two groups(P>0.05).Conclusion The application of Dingkun Pill combined with electrical stimulation therapy in infertility women with thin endometrium can effectively improve endometrial morphology and ovulatory function,and thus increasing the pregnancy rate.
作者
吴浩
张婧
WU Hao;ZHANG Jing(Department of Obstetrics and Gynecology,Xiangyang Central Hospital,Affiliated Hospital of Hubei University of Arts and Science,Xiangyang 441000,Hubei,China)
出处
《中华中医药学刊》
北大核心
2025年第9期238-242,共5页
Chinese Archives of Traditional Chinese Medicine
基金
湖北省自然科学基金面上项目(2017CFB335)。
关键词
定坤丹
电刺激
子宫内膜型不孕症
子宫内膜形态
排卵功能
Dingkun Pill(定坤丹)
electrical stimulation therapy
infertility due to thin endometrium
endometrial morphology
ovulatory function
