摘要
目的探讨麝香通心滴丸联合“坐式八段锦”对射血分数保留的心力衰竭(HFpEF)患者运动耐力、心功能和生活质量的影响,为临床优化射血分数保留心力衰竭综合管理提供依据。方法采用随机对照设计试验,将符合纳入标准的HFpEF患者100例随机分为对照组和观察组,各50例。对照组给予口服麝香通心滴丸(2丸/次,3次/d,连续12周)+常规药物治疗+常规护理干预措施(病情监测、用药指导、低盐饮食建议);观察组在对照组药物治疗+常规护理干预的基础上联合“坐式八段锦”,1次/d,30 min/次(前2周由护士现场指导,后续患者自行练习,每周通过视频随访监督依从性)。连续干预12周后,观察并记录两组患者运动耐力(6分钟步行试验)、心功能(N端脑钠肽前体、心排出量、左心室舒张末期内径)、生活质量(堪萨斯城心肌病问卷简表)方面的差异。结果联合方案的严密实施,促使观察组患者在运动耐力、心功能、生活质量方面有着更为优异的变化趋势:观察组6分钟步行距离较基线增加幅度显著高于对照组(P<0.01);观察组N端脑钠肽前体水平下降,心排出量提高,左心室舒张末期内径改善,改善幅度均优于对照组(P<0.05)。观察组堪萨斯城心肌病问卷简表(KCCQ-12)各维度评分较对照组改善明显,差异有统计学意义(P<0.01)。结论麝香通心滴丸联合“坐式八段锦”能够促进HFpEF患者运动耐力的提升,改善心功能和生活质量。
Objective To investigate the effect of Shexiang Tongxin dropping pills combined with Sitting Baduanjin exercise on exercise tolerance,cardiac function,and quality of life in pa⁃tients with heart failure with preserved ejection fraction(HFpEF),and provide reference for com⁃prehensive management of HFpEF.Methods A randomized controlled tail was conducted,and 100 HFpEF patients were divided into the control group(n=50)and observation group(n=50).All patients received routine treatment and nursing including illness condition monitoring,medica⁃tion guildance,low-salt diet and so on.Patients in the control group received oral medication of Shexiang Tongxin dropping pills(2 pills per time,3 times per day for 12 weeks),and patients in the observation group were given oral medication of Shexiang Tongxin dropping pills combined with Sitting Baduanjin exercise(30 min per time,1 time per day;nurse-guided exercise for first two weeks,video-assisted follow-up).Changes in exercise tolerance(6-minute walking distance test),cardiac function(N-terminal pro-brain natriuretic peptide,cardiac output,left ventricular end-diastolic diameter),and quality of life(the Kansas City Cardiomyopathy Questionnaire Short Form-12,KCCQ-12)were measured and compared between two groups.Results A longer dis⁃tance of 6-minute walking distance test was achieved in patients of observation group compared with that of control group after intervention(P<0.01).Patients in the observation group had lower level of N-terminal pro-brain natriuretic peptide,higher cardiac output and better improve⁃ment in left ventricular end-diastolic diameter compared with those in the control groups(P<0.05).Higher subscale scores of KCCQ-12 were reported in the observation group compared with those in the control group after intervention(P<0.01).Conclusion The Shexiang Tongxin dropping pills combined with Sitting Baduanjin exercise is effective to improve the exercise toler⁃ance,cardiac function,and quality of life in patients with HFpEF.
作者
潘逗逗
李稳
王家美
PAN Doudou;LI Wen;WANG Jiamei(Department of Cardiovascular Medicine,The Second Affiliated Hospital of Navy Medical University,Shanghai,200003)
出处
《中西医结合护理》
2025年第8期60-64,共5页
Chinese Journal of Integrative Nursing
关键词
麝香通心滴丸
坐式八段锦
射血分数保留心力衰竭
运动耐力
心功能
生活质量
Shexiang Tongxin dropping pills
Sitting Baduanjin exercise
heart failure with preserved ejection fraction
exercise tolerance
cardiac function
quality of life
