摘要
高尿酸血症是嘌呤代谢障碍引起血尿酸升高的一种慢性代谢性疾病,可归属于中医学“血浊”范畴,本团队命名其为“酸浊”,其发病与清浊的动态演变密切相关。随着现代人饮食结构的改变,嗜食肥甘、饮酒过度等因素导致高尿酸血症的发病率逐年增加,故本文以“滞伤脾胃”理论为指导详论该病,认为滞伤脾胃、清浊反作、酸浊内生是该病的关键病机。病之初酸浊内蕴,升降失常;病之渐积滞生热,酸浊酿毒;病之极久滞生虚,清浊反作,临床可归纳为湿浊内蕴证、湿热毒蕴证、脾虚湿热证三个证候。因此,本文提出以升清降浊为治疗核心,灵活运用运、消、化三法,分证论治,证属湿浊内蕴则运脾利湿,证属湿热毒蕴则消积泄热,证属脾虚湿热则化浊清热。升清降浊,使“清浊归原”,脾胃安和,升降有序,则高尿酸血症得瘥。
Hyperuricemia is a chronic metabolic disease resulting from purine metabolic dysfunction and is classified under the category of"blood turbidity"in traditional Chinese medicine.Our team termed it"acid turbidity,"and its pathogenesis is closely related to the dynamic evolution of the clear and the turbid components.With the change of modern people′s diet structure,the incidence of hyperuricemia is increasing annually owing to the intake of fatty,sweet foods and alcohol.Therefore,this paper explores hyperuricemia from the"indigestion of spleen and stomach"theory.The core pathogenesis of hyperuricemia is indigestion of spleen and stomach,the inversion of clear and turbid substances,and endogenous acid turbidity.The initial manifestation of hyperuricemia is the internal retention of acid turbidity and ascending-descending disharmony;the gradual manifestation of this disease is that indigestion causes heat,and acid turbidity transforms into poison;the final manifestation of this disease is that secular indigestion causes deficiency and the inversion of clear and turbid substances.It can be summarized into three syndromes:syndromes of internal retention of dampness-turbidity,dampness-heat toxin amassment,and dampness-heat due to spleen deficiency.Therefore,this paper proposes to treat the disease according to different syndromes,with ascending the clear and descending the turbid as the core of treatment.And the therapeutic approach employs the flexible application of three methods:transportation,resolving,and transformation.For syndrome of internal retention of dampness-turbidity,treatment focuses on promoting spleen transportation to eliminate dampness;for syndrome of dampnessheat toxin amassment,the strategy is to resolve indigestion and purge heat;and for syndrome of dampness-heat due to spleen deficiency,the aim is to resolve turbidity and clear heat.By ascending the clear and descending the turbid,so that"returning the clear and the turbid to the original,"the spleen and stomach regain harmony,functions of ascending and descending are reestablished,and hyperuricemia can be effectively managed.
作者
肇起巍
刘昱灼
王梦真
罗玥
刘子玉
南明花
白长川
李欣宇
李佳
杨潇
ZHAO Qiwei;LIU Yuzhuo;WANG Mengzhen;LUO Yue;LIU Ziyu;NAN Minghua;BAI Changchuan;LI Xinyu;LI Jia;YANG Xiao(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110034,China;Central Hospital Affiliated to Dalian University of Technology,Dalian 116033,China)
出处
《北京中医药大学学报》
北大核心
2025年第8期1134-1139,共6页
Journal of Beijing University of Traditional Chinese Medicine
基金
辽宁省自然科学基金面上项目(No.2024-MSLH-255)
2024年度中华中医药学会联合攻关项目(No.2024DYPLHGG-02)。
关键词
高尿酸血症
滞伤脾胃
清浊归原
酸浊
hyperuricemia
indigestion of spleen and stomach
returning the clear and the turbid to the original
acid turbidity
