摘要
系统性红斑狼疮(SLE)是一种病因复杂、多系统受累的慢性自身免疫性疾病。在西医领域,治疗策略已从传统的糖皮质激素和免疫抑制剂为基础,向靶向生物制剂及个体化治疗方案深化,显著提升了疾病控制率,但长期用药的安全性问题仍是研究焦点。在中医领域,研究逐步从经验性辨证论治向现代化、客观化探索,诸多研究证实活血化瘀、清热解毒等治法与黄连、雷公藤等多味中药及其活性成分具有调节免疫炎症网络、减轻激素副作用、改善患者生活质量的潜在机制与临床价值。基于此,梳理近年来中西医两套体系各自的临床研究文献,以期为SLE的临床诊治与未来研究方向提供更全面的参考。
Systemic Lupus Erythematosus(SLE)is a chronic autoimmune disease with complex etiology and multiple-system involvement.In the field of Western medicine,treatment strategies have evolved from being based on traditional glucocorticoids and immunosuppressants to targeted biological agents and individualized treatment plans,which has significantly improved disease control rates.However,the safety issue of long-term medication remains a research focus.In the field of traditional Chinese medicine,research has gradually shifted from empirical syndrome differentiation and treatment to modern and objective exploration.Numerous studies have confirmed that therapeutic methods such as promoting blood circulation and removing blood stasis,clearing heat and detoxifying,as well as various traditional Chinese medicines like Coptischinensis and Tripterygium wilfordii and their active ingredients have potential mechanisms and clinical value in regulating the immune inflammatory network,reducing side effects of hormone,and improving the quality of life of patients.This article reviews the clinical research literature of the two systems of traditional Chinese and Western medicine in recent years,so as to provide a more comprehensive reference for the clinical diagnosis and treatment of SLE and future research directions.
作者
王甘林
庞学丰
WANG Ganlin;PANG Xuefeng(Guangxi University of Chinese Medicine,Nanning 530000,Guangxi,China;Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine,Nanning 530000,Guangxi,China)
出处
《现代诊断与治疗》
2025年第8期1132-1135,共4页
Modern Diagnosis and Treatment
关键词
系统性红斑狼疮
中西医
临床研究
Systemic lupus erythematosus
Traditional Chinese and western medicine
Clinical research
